Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study

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dc.creatorRaquel Gusmão Soares
dc.creatorLucyana Conceição Farias
dc.creatorAgna Soares da Silva Menezes
dc.creatorCarla Silvana de Oliveira e Silva
dc.creatorAngeliny Tamiarana Lima Tabosa
dc.creatorPablo Vinicyus Ferreira Chagas
dc.creatorLaís Santiago
dc.creatorSergio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-22T13:46:22Z
dc.date.accessioned2025-09-08T23:32:33Z
dc.date.available2022-08-22T13:46:22Z
dc.date.issued2018-06-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s10103-018-2549-y
dc.identifier.issn1435-604X
dc.identifier.urihttps://hdl.handle.net/1843/44435
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofLasers in Medical Science
dc.rightsAcesso Aberto
dc.subjectBoca - Câncer
dc.subjectLasers em medicina
dc.subjectFototerapia
dc.subjectCarcinoma de células escamosas
dc.titleTreatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study
dc.typeArtigo de periódico
local.citation.epage1819
local.citation.spage1813
local.citation.volume33
local.description.resumoOral squamous cell carcinoma (OSCC) is the most frequent oral malignant neoplasia. As consequence of OSCC treatment, oral mucositis (OM) is one of the most common adverse effects of OSCC treatment. Currently, there is no consensus for OM treatment. The purpose of the current study was to test the combination of red and infrared low-level laser therapy (LLLT) for OM treatment. Primary culture of human fibroblast was performed to identify LLLT dose. After laboratory tests, a two-arm parallel, single-blind, controlled study was conducted. The two arms were group 1, both 660- and 808-nm wavelengths (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2), and group 2, only 660-nm wavelength (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2). Both treatments were performed twice a week. Group 1 presented a reduction of mucositis grade in comparison to group 2. Group 1 also presented reduction of analgesics prescription. But no significant differences between groups 1 and 2 were observed according to the pain scale. In conclusion, the current study demonstrated that a combination of red and infrared at a higher dose (300 J/cm2) reduced both oral mucositis grade and analgesics prescription. The effects of the combination of RT and LLLT are unclear and need more studies.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10103-018-2549-y

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