Avaliação de Fatores de Risco associados a complicações e óbitos em pacientes pediátricos com Meningite Bacteriana confirmada

Abstract

Bacterial meningitis infections are prevalent worldwide and are considered a serious public health problem because of high morbidity and mortality. The identification of risk factors causing severe outcomes in children diagnosed with meningitis helps to define patients who could benefit from aggressive therapeutic interventions to reduce the unfavorable prognosis. Objectives: The aim of this study was to define the risk factors associated with suppurative complications, short-term sequelae, and death in pediatric patients with bacterial meningitis in the state of Minas Gerais. Methods: A retrospective cohort study in children diagnosed with bacterial meningitis, aged from 0 moths to 18 years, admitted to Hospital Infantil João Paulo II, from January 2005 to December 2018. Results: After multivariate analysis, there was an association of the etiological agents Spn (p 0.006) and H. influenzae type B (p 0.004) with neurological sequelae during hospital discharge. Age less than 1 year during diagnosis (p 0.008; RR 16.26 [95% CI, 2.06-128.6]) and seizures (p 0.038; RR 2.53 [95% CI, 1.05-6.08]) were the independent risk factors for suppurative complications. Death were associated with the presence of gastrointestinal symptoms (p 0.02; RR 5.066 [95% CI, 1.29-19.87]), along with signs of clinical severity (p 0.015; RR 3.453 [1.27-9.39]).