Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism

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dc.creatorGabriela Cavazza Cerri
dc.creatorSérgio Henrique Sousa Santos
dc.creatorMichael Bader
dc.creatorRobson Augusto Souza dos Santos
dc.date.accessioned2024-10-09T20:55:53Z
dc.date.accessioned2025-09-08T23:01:48Z
dc.date.available2024-10-09T20:55:53Z
dc.date.issued2023-04
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2023.109268
dc.identifier.issn1873-4847
dc.identifier.urihttps://hdl.handle.net/1843/77347
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectSistema renina-angiotensina
dc.subjectTecido adiposo marrom
dc.subjectAlanina
dc.subjectObesidade
dc.titleBrown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism
dc.typeArtigo de periódico
local.citation.spage109268
local.citation.volume114
local.description.resumoAlamandine is a recently described heptapeptide component of the renin-angiotensin system (RAS), and its effects are mediated by the receptor Mas-related G protein-coupled receptor D (MrgD) RAS represents an important link between obesity and its consequences by directly modulating the thermogenesis and brown adipose tissue (BAT) function. The alamandine/MrgD metabolic effects and signaling remain unexplored. In this context, the main goal of the present study was to assess the metabolic consequences of MrgD genetic ablation in C57BL6/J mice by evaluating brown adipose tissue RNA sequencing. The main results showed that MrgD-KO mice have diminished brown adipose tissue and that a high-glucose diet (HG) decreased both circulating alamandine levels and MrgD expression in BAT from wild-type mice (WT). BAT transcriptome reveals that MrgD-KO HG mice regulated 45 genes, while WT HG mice regulated 1,148 genes. MrgD-KO mice fed a standard diet (ST) compared with WT ST mice regulated 476 genes, of which 445 genes were downregulated. BAT uses the MrgD receptor to display a normal pattern of gene expression and to respond, like WT mice, to an HG diet. In conclusion, the MrgD signaling is important for the metabolic regulation and manutention of BAT functionality.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0955286323000025

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