A comparative analysis of three online drug-drug interaction checkers: a short communication

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dc.creatorDiego Rodrigues de Aguilar
dc.creatorAlex Junio Silva Cruz
dc.creatorMaria Auxiliadora Parreiras Martins
dc.creatorMauro Henrique Nogueira Guimarães Abreu
dc.date.accessioned2026-02-13T21:24:27Z
dc.date.issued2024-05-24
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1590/pboci.2024.044
dc.identifier.issn1983-4632
dc.identifier.urihttps://hdl.handle.net/1843/1661
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPesquisa Brasileira em Odontopediatria e Clínica Integrada
dc.rightsAcesso aberto
dc.subjectMedicamentos - Interação
dc.subjectPacientes odontológicos
dc.subjectEstudo transversal
dc.subjectEstudo transversal
dc.subject.otherDentistry
dc.subject.otherPsychotropic drugs
dc.subject.otherDrug interactions
dc.subject.otherDecision support systems
dc.subject.otherClinical
dc.subject.otherPatient safety
dc.titleA comparative analysis of three online drug-drug interaction checkers: a short communication
dc.typeArtigo de periódico
local.citation.epage6
local.citation.spage1
local.citation.volume24
local.creator.Latteshttp://lattes.cnpq.br/4405925489665474
local.creator.Latteshttp://lattes.cnpq.br/0431050314405943
local.description.resumoObjective: To assess the agreement among three different online drug-drug interaction (DDI) checkers for the detection of psychotropic drug interactions among dental patients in the state of Minas Gerais, Brazil. Material and Methods: Between January and December 2017, a cross-sectional study was conducted in Minas Gerais with data on pharmaceutical claims of psychotropic drugs prescribed by dental practitioners. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The occurrence of DDI was determined by entering the name of the drugs taken by each patient into Merative Micromedex®, Medscape®, and DrugBank. The degree of agreement among the three DDI online checkers was analyzed using the Fleiss' kappa test. Results: Overall, 797 dental patients were found to be taking some psychotropic medication with other drugs simultaneously. The number of patients with DDI varied according to Micromedex® (n= 366), Medscape® (n= 473), and DrugBank (n= 736). The agreement between the DDI checkers was poor (Fleiss' kappa: 0.165; p<0.001). Conclusion: The online DDI checkers assessed in this study showed variations in their ability to detect interactions and poor agreement among them.
local.identifier.orcidhttps://orcid.org/0000-0003-2667-9229
local.identifier.orcidhttps://orcid.org/0000-0003-1905-4124
local.identifier.orcidhttps://orcid.org/0000-0002-5211-411X
local.identifier.orcidhttps://orcid.org/0000-0001-8794-5725
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS DA SAUDE
local.url.externahttps://www.scielo.br/j/pboci/a/K7Lmv43JwfCDhkndr8QmnYd/?lang=en#top

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