Regional myocardial perfusion disturbance in experimental chronic chagas cardiomyopathy

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dc.creatorLuciano Fonseca Lemos de Oliveira
dc.creatorJames Thackeray
dc.creatorJosé Antônio Marin Neto
dc.creatorMinna Moreira Dias Romano
dc.creatorEduardo Elias Vieira de Carvalho
dc.creatorJorge Mejia
dc.creatorDenise Mayumi Tanaka
dc.creatorGrace Kelly da Silva
dc.creatorDouglas Reis Abdalla
dc.creatorCarlos Malamut
dc.creatorFrank Bengel
dc.creatorMaria de Lourdes Higuchi
dc.creatorAndré Schmidt
dc.creatorEdécio Cunha Neto
dc.creatorMarcus Vinicius Simões
dc.date.accessioned2022-12-12T18:55:57Z
dc.date.accessioned2025-09-09T00:55:00Z
dc.date.available2022-12-12T18:55:57Z
dc.date.issued2018-09
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.identifier.doihttps://doi.org/10.2967/jnumed.117.205450
dc.identifier.issn0161-5505
dc.identifier.urihttps://hdl.handle.net/1843/47881
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Nuclear Medicine
dc.rightsAcesso Restrito
dc.subjectCardiomiopatia chagásica
dc.subjectReperfusão miocárdica
dc.subjectMiocardite
dc.subject.otherChronic Chagas cardiomyopathy
dc.subject.otherMyocardial perfusion
dc.subject.otherMyocardial inflammation
dc.titleRegional myocardial perfusion disturbance in experimental chronic chagas cardiomyopathy
dc.typeArtigo de periódico
local.citation.epage1436
local.citation.issue9
local.citation.spage1430
local.citation.volume59
local.description.resumoAltered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of myocardial perfusion defects (MPDs) and the correlated regional changes to histology in an experimental model of CCC in hamsters. Methods: Female Syrian hamsters (n = 34) were infected with 3.5 × 104 to 105 trypomastigote forms of Trypanosoma cruzi, Y strain, and 6–10 mo afterward underwent in vivo imaging including resting 99mTc-sestamibi SPECT, segmental and global left ventricular function assessment using 2-dimensional echocardiography, and 18F-FDG PET for evaluation of myocardial viability. Histologic analysis included quantification of fibrosis, inflammatory infiltration, and the diameter and density of myocardial microcirculation. Results: MPDs were present in 17 (50%) of the infected animals. Histologic analysis revealed no transmural scar in segments with an MPD, and normal or mildly reduced 18F-FDG uptake, indicating viable myocardium. Infected animals with an MPD, in comparison to infected animals without an MPD and control animals, showed a lower left ventricular ejection fraction (P = 0.012), a higher wall motion score index (P = 0.004), and a higher extent of inflammatory infiltration (P = 0.018) but a similar extent of fibrosis (P = 0.15) and similar microvascular diameter and density (P > 0.05). Segments with an MPD (n = 65), as compared with normally perfused regions in the same animal (n = 156), showed a higher wall motion score index (P = 0.005) but a similar extent of inflammatory infiltration, a similar extent of fibrosis, and a similar microvascular diameter and density. Conclusion: Resting MPDs are frequent in experimental CCC and are associated with myocardial inflammation but do not designate scar tissue, corresponding to regions with metabolically viable myocardium.
local.identifier.orcidhttps://orcid.org/0000-0003-3455-2463
local.identifier.orcidhttps://orcid.org/0000-0002-2526-0656
local.identifier.orcidhttps://orcid.org/0000-0001-5026-335X
local.identifier.orcidhttps://orcid.org/0000-0002-5035-9172
local.identifier.orcidhttps://orcid.org/0000-0002-6971-1201
local.identifier.orcidhttps://orcid.org/0000-0003-4529-7963
local.identifier.orcidhttps://orcid.org/0000-0002-1673-6456
local.identifier.orcidhttps://orcid.org/0000-0002-1090-8165
local.identifier.orcidhttps://orcid.org/0000-0002-3699-3345
local.identifier.orcidhttps://orcid.org/0000-0001-6553-8387
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://jnm.snmjournals.org/content/59/9/1430.long

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