Avaliação dos parâmetros salivares e dos compostos sulfurados voláteis dos pacientes com câncer em cabeça e pescoço, durante o tratamento oncológico

Abstract

OBJECTIVE: The aim of this study was to investigate changes in salivary parameters and levels of volatile sulfur compounds (VSC) during the oncological treatment in patients with squamous cell carcinoma of the head and neck. MATERIALS AND METHODS:clinical study segmentedin which 24 patients were examined in two stages: before starting treatment with radiotherapy and chemotherapy and after the end of the 39 radiotherapy sessions. Evaluation of the presence of tongue coating was performed during clinical examination. The salivary evaluated parameters were: salivary flow at unstimulated and stimulated which were collected during 05 minutes in a graph Falcon tube. For the stimulated saliva used the hyperboloid (chewing instrument); the viscosity by viscometer Ostwald modified (Cannon-FrenskeRoutine model); pH was measured with a portable digital pH meter (model Checker® 1 - HI98103). The evaluation was made by the CSV method of gas chromatography using Oral ChromaTM. The VAS scale was recorded at values from zero to ten, with the sensation of dry mouth patients. The results were analyzed using SPSS version 17.0 with 95% confidence level. RESULTS: The results showed a statistically significant reduction in salivary flow stimulated and unstimulated (p = 0.0002 and p = 0.0005 respectively) and pH (p = 0.0151). A significant increase in viscosity after the treatment (p = 0.0420) and an increase of xerostomia (p <0.0001). The CSV concentrations did not change after treatment. CONCLUSION: These results demonstrate that cancer treatment causes a reduced salivary flow and pH, increased viscosity and xerostomia. The CSV concentrations did not change after treatment, even occurring changes in salivary parameters.