An update on the current management of head and neck mucosal melanoma

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dc.creatorBen Green
dc.creatorAhmed S. Elhamshary
dc.creatorRicardo Santiago Gomez
dc.creatorSiavash Rahimi
dc.creatorPeter A. Brennan
dc.date.accessioned2024-12-12T20:25:21Z
dc.date.accessioned2025-09-08T23:48:27Z
dc.date.available2024-12-12T20:25:21Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12526
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/78640
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Aberto
dc.subjectRadiotherapy
dc.subjectNeoplasm staging
dc.subjectMargins of excision
dc.subjectNeoadjuvant therapy
dc.subjectRadiotherapy, adjuvant
dc.subjectNeoplasms
dc.subjectInhibitors, tyrosine kinase
dc.subjectStem cell factor
dc.subjectPrognosis
dc.subjectDiagnosis
dc.subject.otherHead and neck
dc.subject.otherMucosal melanoma
dc.subject.otherStaging
dc.subject.otherSurgery
dc.subject.otherRadiotherapy
dc.subject.otherSystemic therapy
dc.titleAn update on the current management of head and neck mucosal melanoma
dc.typeArtigo de periódico
local.citation.epage479
local.citation.issue7
local.citation.spage475
local.citation.volume46
local.description.resumoPrimary mucosal melanomas of the head and neck are rare and aggressive tumours that arise in the nasal cavity, paranasal sinuses and more rarely in the oral cavity. The current treatment options include radical surgical resection with adjuvant external beam radiotherapy being offered in high-risk patients. Although the latter can improve regional control, it does not reduce overall survival. Elective neck dissection is recommended for nodular oral mucosal melanoma, but its role in the clinically node negative neck is controversial. Systemic therapies including the use of tyrosine kinase inhibitors for tumours with c-KIT mutations are suitable for patients with advanced loco-regional and/or metastatic disease, but current results are variable. Patients with head and neck mucosal melanoma have a poor prognosis due to the high incidence of metastatic disease. This review assesses the latest evidence in the diagnosis and management of primary oral and head and neck mucosal melanoma including details of systemic therapies.
local.identifier.orcidhttps://orcid.org/0000-0002-4456-1921
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0002-8282-1480
local.identifier.orcidhttps://orcid.org/0000-0003-4804-3264
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12526

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