Microbiota is an essential element for mice to initiate a protective immunity against Vaccinia virus

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dc.creatorMauricio Teixeira Lima
dc.creatorFlaviano Dos Santos Martins
dc.creatorJonatas Santos Abrahão
dc.creatorAna Cláudia Dos Santos Pereira Andrade
dc.creatorGraziele P. Oliveira
dc.creatorRafael S. Calixto
dc.creatorDanilo B. Oliveira
dc.creatorÉricka Lorena de Sales Souza
dc.creatorGiliane S. Trindade
dc.creatorJacques R. Nicoli
dc.creatorErna Geessien Kroon
dc.date.accessioned2025-02-05T23:19:36Z
dc.date.accessioned2025-09-09T01:15:34Z
dc.date.available2025-02-05T23:19:36Z
dc.date.issued2016-11-26
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1093/femsec/fiv147
dc.identifier.issn1574-6941
dc.identifier.urihttps://hdl.handle.net/1843/79688
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFEMS Microbiology Ecology
dc.rightsAcesso Aberto
dc.subjectVacinas
dc.subjectMicrobiologia
dc.subjectRatos como animais de laboratório
dc.subject.otherMicrobiota
dc.subject.otherVaccinia virus
dc.subject.otherVirus–microbiota interactions
dc.subject.otherGerm-free mice
dc.titleMicrobiota is an essential element for mice to initiate a protective immunity against Vaccinia virus
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume92
local.description.resumoThe gastrointestinal tract of vertebrates harbors one of the most complex ecosystems known in microbial ecology and this indigenous microbiota almost always has a profound influence on host–parasite relationships, which can enhance or reduce the pathology of the infection. In this context, the impact of the microbiota during the infection of several viral groups remains poorly studied, including the family Poxviridae. Vaccinia virus (VACV) is a member of this family and is the causative agent of bovine vaccinia, responsible for outbreaks that affect bovines and humans. To determine the influence of the microbiota in the development of the disease caused by VACV, a comparative study using a murine model was performed. Germ-free and conventional, 6- to 7-week-old Swiss NIH mice were infected by tail scarification and intranasally with VACV. Moreover, immunosuppression and microbiota reposition were performed, to establish the interactions among the host’s immune system, microbiota and VACV. The data demonstrate that the microbiota is essential for the effective immune response of mice against VACV in intranasal inoculation and to control the virus at the primary site of infection. Furthermore, this study is the first to show that Swiss conventional mice are refractory to the intranasal infection of VACV
local.identifier.orcidhttps://orcid.org/0000-0002-0830-3909
local.identifier.orcidhttps://orcid.org/0000-0003-0741-3062
local.identifier.orcidhttps://orcid.org/0000-0001-9420-1791
local.identifier.orcidhttps://orcid.org/0000-0001-9724-4164
local.identifier.orcidhttps://orcid.org/0000-0002-8521-0351
local.identifier.orcidhttps://orcid.org/0000-0003-4780-8499
local.identifier.orcidhttps://orcid.org/0000-0002-6973-7751
local.identifier.orcidhttps://orcid.org/0000-0003-0785-4298
local.identifier.orcidhttps://orcid.org/0000-0003-2390-2608
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/femsec/article-pdf/92/2/fiv147/10738728/fiv147.pdf

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