Wild-type yellow fever virus in cerebrospinal fluid from fatal cases in Brazil, 2018

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dc.creatorIzabela Mauricio de Rezende
dc.creatorAdriana Regina Campolina Cenachi
dc.creatorThais Alkifeles Costa
dc.creatorGabriela Fernanda Garcia Oliveira
dc.creatorLivia Rabelo
dc.creatorLeticia Mattos Menezes
dc.creatorIndiara Penido
dc.creatorLeonardo Soares Pereira
dc.creatorMatheus Soares Arruda
dc.creatorAndreza Parreiras Gonçalves
dc.creatorPedro Augusto Alves
dc.creatorErna Geessien Kroon
dc.creatorCarlos Eduardo Calzavara-Silva
dc.creatorDario Brock Ramalho
dc.creatorOlindo Assis Martins-Filho
dc.creatorAndrea Teixeira-Carvalho
dc.creatorAngelle Desiree LaBeaud
dc.creatorBetania Drumond
dc.date.accessioned2025-02-17T22:56:32Z
dc.date.accessioned2025-09-08T22:49:14Z
dc.date.available2025-02-17T22:56:32Z
dc.date.issued2022-09-09
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fviro.2022.936191
dc.identifier.issn2673-818X
dc.identifier.urihttps://hdl.handle.net/1843/80166
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Virology
dc.rightsAcesso Aberto
dc.subjectVírus da Febre Amarela
dc.subjectSistema Nervoso Central
dc.subjectLíquido Cefalorraquidiano
dc.subject.otherYellow fever virus
dc.subject.otherYellow fever
dc.subject.otherCerebrospinal fluid
dc.subject.otherWild-type Yellow fever virus
dc.subject.otherNeurotropic
dc.subject.otherCentral nervous system
dc.titleWild-type yellow fever virus in cerebrospinal fluid from fatal cases in Brazil, 2018
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume2
local.description.resumoYellow fever virus (YFV) is the causative agent of yellow fever (YF), a hemorrhagic and viscerotropic acute disease. Severe YF has been described in approximately 15-25% of YF patients, with 20-50% of severe YF cases being fatal. Here we analyzed cerebrospinal fluid (CSF) samples collected during the YF outbreak in Brazil in 2018, aiming to investigate CNS neuroinvasion in fatal YFV cases. YFV RNA was screened by RT-qPCR targeting the 3’UTR region of the YFV genome in CSF. CSF samples were tested for the presence of anti-YFV IgM and neutralizing antibodies, coupled with routine laboratory examinations. Among the 13 patients studied, we detected anti-YFV IgM in CSF from eight patients and YFV RNA in CSF from five patients. YFV RNA genomic load in CSF samples ranged from 1.75x103 to 5.42x103 RNA copies/mL. We genotyped YFV from three CSF samples that grouped with other YFV samples from the 2018 outbreak in Brazil within the South-American I genotype. Even though descriptions of neurologic manifestations due to wild type YFV (WT-YFV) infection are rare, since the last YF outbreak in Brazil in 2017-2018, a few studies have demonstrated WT-YFV RNA in CSF samples from YF fatal cases. Serological tests indicated the presence of IgM and neutralizing antibodies against YFV in CSF samples from two patients. Although the presence of viral RNA, IgM and neutralizing antibodies in CSF samples could indicate neuroinvasiveness, further studies are needed to better elucidate the role of YFV neuroinvasion and possible impacts in disease pathogenesis.
local.identifier.orcidhttps://orcid.org/0000-0003-2616-6300
local.identifier.orcidhttps://orcid.org/0000-0003-4802-1815
local.identifier.orcidhttps://orcid.org/0000-0001-8343-6405
local.identifier.orcidhttps://orcid.org/0000-0002-4256-247X
local.identifier.orcidhttps://orcid.org/0000-0002-2741-9405
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0002-1406-6401
local.identifier.orcidhttps://orcid.org/0000-0003-3299-5383
local.identifier.orcidhttps://orcid.org/0000-0002-5494-4889
local.identifier.orcidhttps://orcid.org/0000-0003-2814-5183
local.identifier.orcidhttps://orcid.org/0000-0001-8364-6867
local.identifier.orcidhttps://orcid.org/0000-0002-4049-4055
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/virology/articles/10.3389/fviro.2022.936191/full

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