Microparticles: inflammatory and haemostatic biomarkers in polycystic ovary syndrome

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dc.creatorLaura Machado Lara Carvalho
dc.creatorKarina Braga Gomes
dc.creatorCláudia Natália Ferreira
dc.creatorMirelle Oliveira Sóter
dc.creatorMariana Ferreira Sales
dc.creatorKathryna Fontana Rodrigues
dc.creatorAna Lúcia Cândido
dc.creatorFernando Marcos Dos Reis
dc.creatorIeda de Fátima Oliveira Silva
dc.creatorFernanda Magalhães Freire Campos
dc.date.accessioned2023-10-05T22:59:48Z
dc.date.accessioned2025-09-09T00:21:08Z
dc.date.available2023-10-05T22:59:48Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1016/j.mce.2017.01.017
dc.identifier.issn0303-7207
dc.identifier.urihttps://hdl.handle.net/1843/59237
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecular and Cellular Endocrinology
dc.rightsAcesso Aberto
dc.subjectOvarios
dc.subject.otherPolycystic Ovary Syndrome
dc.subject.otherMicroparticles
dc.subject.otherPlatelets
dc.subject.otherLeukocytes
dc.subject.otherEndothelial cells
dc.subject.otherTissue factor
dc.titleMicroparticles: inflammatory and haemostatic biomarkers in polycystic ovary syndrome
dc.typeArtigo de periódico
local.citation.epage162
local.citation.spage155
local.citation.volume443
local.description.resumoPolycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women.
local.identifier.orcidhttps://orcid.org/0000-0001-5599-2236
local.identifier.orcidhttps://orcid.org/0000-0002-6870-2063
local.identifier.orcidhttps://orcid.org/0000-0003-4545-6821
local.identifier.orcidhttps://orcid.org/0000-0002-4856-7503
local.identifier.orcidhttps://orcid.org/0000-0001-9335-9837
local.identifier.orcidhttps://orcid.org/0000-0002-6792-1707
local.identifier.orcidhttps://orcid.org/0000-0002-9080-2319
local.identifier.orcidhttps://orcid.org/0000-0003-2291-2994
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0303720717300217?via%3Dihub

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