Chemical interactions between monomer and template in molecularly imprinted polymers, the EGDMA:2-VP (4:1) - lumefantrine MIP case study

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dc.creatorMaria Betânia de Freitas Marques
dc.creatorPedro Henrique Reis da Silva
dc.creatorTércio Assunção Pedrosa
dc.creatorMaria Irene Yoshida
dc.creatorChristian Fernandes
dc.creatorWagner da Nova Mussel
dc.date.accessioned2026-02-27T15:19:28Z
dc.date.issued2021
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.30609/jeti.v4i04.14486
dc.identifier.issn2595-1106
dc.identifier.urihttps://hdl.handle.net/1843/1804
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Experimental Techniques and Instrumentation
dc.rightsAcesso aberto
dc.subjectPolímeros
dc.subjectAntimaláricos
dc.subjectMonômeros
dc.subjectMoléculas
dc.subject.otherMolecularly imprinting factor
dc.subject.otherAn antimalarial drug
dc.subject.otherThermal behavior
dc.subject.otherGlass transition
dc.subject.otherElement mapping
dc.subject.otherSorption mechanism
dc.titleChemical interactions between monomer and template in molecularly imprinted polymers, the EGDMA:2-VP (4:1) - lumefantrine MIP case study
dc.title.alternativeInterações químicas entre monômero e molécula molde em polímeros com impressão molecular, o EGDMA: 2-VP (4:1) - estudo de caso MIP lumefantrina
dc.typeArtigo de periódico
local.citation.epage76
local.citation.issue2021
local.citation.spage56
local.citation.volume4
local.creator.Latteshttp://lattes.cnpq.br/8670717808004107
local.creator.Latteshttp://lattes.cnpq.br/1743024742505291
local.creator.Latteshttp://lattes.cnpq.br/9352927306126636
local.creator.Latteshttp://lattes.cnpq.br/6473264538281674
local.creator.Latteshttp://lattes.cnpq.br/2204207812156880
local.creator.Latteshttp://lattes.cnpq.br/3024747722960663
local.description.resumoMolecularly Imprinted Polymers (MIP) are synthetic materials used as a tool to enhance the selectivity in different analytical approaches, such as solid-phase extraction, chromatography, and sensing devices. Knowing the mechanism involved in the interaction between the template and monomer is essential for a further successful application. However, studies on this topic are scarce. This work evaluates the involved mechanisms in the template-monomer interaction for a lumefantrine MIP system, an antimalarial drug. Field-emission gun scanning electron microscopy, thermal analysis, X-ray diffraction, and density functional theory were applied to determine the mechanism involved in two MIPs obtained in different conditions. A new parameter, named Molecularly Imprinting Factor (MIF), was proposed to evaluate the contribution of specific interactions in the sorption of the analyte by the MIP structure. MIF allows direct insights into specific binding, non-specific contributions, interaction nature, behavior predictability, system acid-base behavior, pre-screening pairs capability, and binding site affinities evaluation. Two interaction types were observed, covalent and non-covalent, when methacrylic acid and 2-vinyl pyridine were used as monomers, respectively. Therefore, the use of methacrylic acid formed a sorbent inappropriate for solid-phase extraction since the binding is not reversible. On the other hand, 2-vinyl pyridine-lumefantrine binding was reversible, and MIF = 0.59 (59.02% of specific site sorption) indicates that the predominant mechanism in the sorption is specific.
local.identifier.orcidhttps://orcid.org/0000-0002-0561-2343
local.identifier.orcidhttps://orcid.org/0000-0002-7898-210X
local.identifier.orcidhttps://orcid.org/0009-0000-9996-2709
local.identifier.orcidhttps://orcid.org/0000-0002-6795-9457
local.identifier.orcidhttps://orcid.org/0000-0002-3905-3674
local.identifier.orcidhttps://orcid.org/0000-0002-9768-9830
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS EXATAS E DA TERRA::QUIMICA
local.url.externahttps://periodicos.ufms.br/index.php/JETI/article/view/14486

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