A systematic review and meta-analysis comparing the diagnostic accuracy tests of COVID-19

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dc.creatorJuan Jeferson Vilca-Alosilla
dc.creatorMayron Antonio Candia-Puma
dc.creatorKatiusca Coronel-Monje
dc.creatorLuis Daniel Goyzueta-Mamani
dc.creatorAlexsandro Sobreira Galdino
dc.creatorRicardo Andrez Machado-de-Ávila
dc.creatorRodolfo Cordeiro Giunchetti
dc.creatorEduardo Antonio Ferraz Coelho
dc.creatorMiguel Angel Chávez-Fumagalli
dc.date.accessioned2025-02-10T19:31:04Z
dc.date.accessioned2025-09-08T23:17:12Z
dc.date.available2025-02-10T19:31:04Z
dc.date.issued2023-04-26
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/diagnostics13091549
dc.identifier.issn2075-4418
dc.identifier.urihttps://hdl.handle.net/1843/79829
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDiagnostics
dc.rightsAcesso Aberto
dc.subjectSARS-CoV-2
dc.subjectTécnicas e Procedimentos Diagnósticos
dc.subjectRevisão Sistemática
dc.subjectCOVID-19
dc.subject.otherSARS-CoV-2
dc.subject.otherDiagnostic tests
dc.subject.otherMeta-analysis
dc.subject.otherSystematic review
dc.subject.otherSensitivity
dc.subject.otherSpecificity
dc.titleA systematic review and meta-analysis comparing the diagnostic accuracy tests of COVID-19
dc.typeArtigo de periódico
local.citation.epage30
local.citation.issue9
local.citation.spage01
local.citation.volume13
local.description.resumoIn this paper, we present a systematic review and meta-analysis that aims to evaluate the reliability of coronavirus disease diagnostic tests in 2019 (COVID-19). This article seeks to describe the scientific discoveries made because of diagnostic tests conducted in recent years during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Between 2020 and 2021, searches for published papers on the COVID-19 diagnostic were made in the PubMed database. Ninety-nine scientific articles that satisfied the requirements were analyzed and included in the meta-analysis, and the specificity and sensitivity of the diagnostic accuracy were assessed. When compared to serological tests such as the enzyme-linked immunosorbent assay (ELISA), chemiluminescence immunoassay (CLIA), lateral flow immunoassay (LFIA), and chemiluminescent microparticle immunoassay (CMIA), molecular tests such as reverse transcription polymerase chain reaction (RT-PCR), reverse transcription loop-mediated isothermal amplification (RT-LAMP), and clustered regularly interspaced short palindromic repeats (CRISPR) performed better in terms of sensitivity and specificity. Additionally, the area under the curve restricted to the false-positive rates (AUCFPR) of 0.984 obtained by the antiviral neutralization bioassay (ANB) diagnostic test revealed significant potential for the identification of COVID-19. It has been established that the various diagnostic tests have been effectively adapted for the detection of SARS-CoV-2; nevertheless, their performance still must be enhanced to contain potential COVID-19 outbreaks, which will also help contain potential infectious agent outbreaks in the future.
local.identifier.orcidhttps://orcid.org/0000-0002-4156-0237
local.identifier.orcidhttps://orcid.org/0000-0002-6328-3840
local.identifier.orcidhttps://orcid.org/0000-0002-8570-8715
local.identifier.orcidhttps://orcid.org/0000-0003-0308-1160
local.identifier.orcidhttps://orcid.org/0000-0002-8890-3030
local.identifier.orcidhttps://orcid.org/0000-0002-1303-0490
local.identifier.orcidhttps://orcid.org/0000-0003-4181-7546
local.identifier.orcidhttps://orcid.org/0000-0002-8394-4802
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2075-4418/13/9/1549

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