IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus

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dc.creatorLuiz Alcino Gueiros
dc.creatorTelma Arão
dc.creatorThayse Souza
dc.creatorCamila Lins Vieira
dc.creatorRicardo Santiago Gomez
dc.creatorOslei Paes de Almeida
dc.creatorGiovani Lodi
dc.creatorJair Carneiro Leão
dc.date.accessioned2025-01-07T22:13:38Z
dc.date.accessioned2025-09-08T23:02:37Z
dc.date.available2025-01-07T22:13:38Z
dc.date.issued2018-04
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/odi.12718
dc.identifier.issn1601-0825
dc.identifier.urihttps://hdl.handle.net/1843/79077
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Diseases
dc.rightsAcesso Aberto
dc.subjectDisease susceptibility
dc.subjectPolymorphism, genetic
dc.subjectInterleukin-17
dc.subjectLichen planus, oral
dc.subjectTh17 cells
dc.subject.otherDisease susceptibility
dc.subject.otherGenetic polymorphism
dc.subject.otherInterleukin 17
dc.subject.otherOral lichen planus
dc.titleIL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus
dc.typeArtigo de periódico
local.citation.epage383
local.citation.issue3
local.citation.spage377
local.citation.volume24
local.description.resumoObjective: The aim of this study was to evaluate the association of IL17A G197A polymorphism and serum levels with oral lichen planus (OLP) susceptibility and clinical presentation. Subjects and methods: Eighty-three individuals diagnosed with OLP and 99 healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and DNA isolated for IL17A (G197A) genotyping. Blood samples of 42 OLP individuals and 23 healthy controls were collected for evaluation of IL17A serum levels. Results: IL17A G197A genotypes were associated with an increased chance of having OLP (GA/AA × GG, OR = 3.44, 95% CI = 1.87-6.33, p < .001). Overall A carriers (GA or AA) were more common in OLP (38.1%) than in C (20.2%; OR = 2.43, 95% CI = 1.53-3.87, p < .001). Serum levels of IL17A were higher among patients with OLP than in healthy controls (reticular, p = .0003; erosive, p < .001), but no difference was found among the disease types. Conclusions: IL17A G197A is associated with a higher susceptibility of developing OLP and these patients seem to present a considerable increase in IL17A serum levels. These findings suggest that Th17 cells, and IL17A in particular, may play a pivotal role in OLP pathogenesis.
local.identifier.orcidhttps://orcid.org/0000-0003-4979-4318
local.identifier.orcidhttps://orcid.org/0000-0001-6920-5934
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0003-2002-8003
local.identifier.orcidhttps://orcid.org/0000-0001-8303-2291
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.12718

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