Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens

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dc.creatorLaise Carolina França
dc.creatorAlice Laschuk Herlinger
dc.creatorRenato Santana de Aguiar
dc.creatorOrlando da Costa Ferreira Junior
dc.creatorFernando Faria Andrade Figueira
dc.creatorJorge Paes Barreto Marcondes de Souza
dc.creatorJoelma Freire de Mesquita
dc.creatorSoniza Vieira Alves-leon
dc.creatorFabrícia Lima Fontes-dantas
dc.creatorDiogo Gomes Garcia
dc.creatorAmanda Dutra de Araújo
dc.creatorJoão Paulo da Costa Gonçalves
dc.creatorCláudia Cecília da Silva Rêgo
dc.creatorElielson Veloso da Silva
dc.creatorOsvaldo José Moreira do Nascimento
dc.creatorFernanda Cristina Rueda Lopes
dc.date.accessioned2025-01-24T21:12:54Z
dc.date.accessioned2025-09-09T00:33:54Z
dc.date.available2025-01-24T21:12:54Z
dc.date.issued2023-04
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1055/S-0043-1768698
dc.identifier.issn0004-282X
dc.identifier.urihttps://hdl.handle.net/1843/79481
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsAcesso Aberto
dc.subjectVírus da Zika
dc.subjectMimetismo (Biologia)
dc.subjectMicrobiologia
dc.subjectEsclerose múltipla
dc.subject.otherZika virus
dc.subject.otherDemyelinating diseases
dc.subject.otherMolecular mimicry
dc.subject.otherViral nonstructural proteins
dc.subject.otherMultiple sclerosis
dc.titleMolecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens
dc.title.alternativeMimetismo molecular entre o vírus Zika e os distúrbios inflamatórios desmielinizantes do sistema nervoso central: o papel do epítopo NS5 do vírus Zika e dos autoantígenos PLP
dc.typeArtigo de periódico
local.citation.epage368
local.citation.issue4
local.citation.spage357
local.citation.volume81
local.description.resumoBackground Evidence indicates a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (HDD) after ZikV infection have been reported in Brazil. Objective The present study aims to investigate the possible occurrence of molecular mimicry between ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent HDD of the central nervous system (CNS). Methods A retrospective cohort study with 305 patients admitted due to suspected arbovirus infection in Rio de Janeiro was performed, all subjects were submitted to neurological examination, and a biological sample was collected for serologic and molecular diagnostic. Bioinformatics tools were used to analyze the peptides shared between ZikV antigens and MS autoantigens. Results Of 305 patients, twenty-six were positive for ZikV and 4 presented IDD patterns found in MS cases. Sequence homology comparisons by bioinformatics approach between NS5 ZikV and PLP MS protein revealed a homology of 5/6 consecutive amino acids (CSSVPV/CSAVPV) with 83% identity, deducing a molecular mimicry. Analysis of the 3D structures revealed a similar conformation with alpha helix presentation. Conclusions Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals.
local.identifier.orcidhttps://orcid.org/0000-0001-8851-7845
local.identifier.orcidhttps://orcid.org/0000-0002-7660-7058
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0002-1970-8936
local.identifier.orcidhttps://orcid.org/0000-0003-3242-9007
local.identifier.orcidhttps://orcid.org/0000-0003-2412-8239
local.identifier.orcidhttps://orcid.org/0000-0003-1684-3830
local.identifier.orcidhttps://orcid.org/0000-0002-1538-6730
local.identifier.orcidhttps://orcid.org/0000-0003-2621-3138
local.identifier.orcidhttps://orcid.org/0000-0002-3434-1589
local.identifier.orcidhttps://orcid.org/0000-0001-6233-1428
local.identifier.orcidhttps://orcid.org/0000-0002-1837-4401
local.identifier.orcidhttps://orcid.org/0000-0002-5201-0927
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/anp/a/QKCjMKWWSFRHSg4xC8bhdnb/abstract/?lang=en

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