Trypanocidal activity and increased solubility of benznidazole incorporated in PEG 4000 and its derivatives

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dc.creatorLucas Resende Dutra Sousa
dc.creatorCláudia Martins Carneiro
dc.creatorAna Paula Moreira Barboza
dc.creatorBernardo Ruegger Almeida Neves
dc.creatorPolicarpo Ademar Sales Junior
dc.creatorSilvane Maria Fonseca Murta
dc.creatorKátia Monteiro Novack
dc.creatorViviane Martins Rebello dos Santos
dc.creatorMaria Luíza Schaefer Azevedo
dc.creatorDayana Ferreira Rocha
dc.creatorÂngela Leão Andrade
dc.creatorTatiane Roquete Amparo
dc.creatorOrlando David Henrique dos Santos
dc.creatorJanaina Brandão Seibert
dc.creatorLuciano R. Pereira
dc.creatorPaula Melo de Abreu Vieira
dc.date.accessioned2023-07-11T11:59:06Z
dc.date.accessioned2025-09-09T00:27:41Z
dc.date.available2023-07-11T11:59:06Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://dx.doi.org/10.21577/0103-5053.20210017
dc.identifier.issn1678-4790
dc.identifier.urihttps://hdl.handle.net/1843/56051
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subjectDoença de Chagas
dc.subjectPolímeros
dc.subject.otherBenznidazole
dc.subject.otherChagas disease
dc.subject.otherCytotoxicity
dc.subject.otherMicroparticles
dc.subject.otherPolymer
dc.titleTrypanocidal activity and increased solubility of benznidazole incorporated in PEG 4000 and its derivatives
dc.typeArtigo de periódico
local.citation.epage1172
local.citation.issue6
local.citation.spage1162
local.citation.volume32
local.description.resumoSelecting a polymer depends on its characteristics, the properties of the drug and of the remaining ingredients in the formulation. The drug, when incorporated into a polymeric matrix, can show several advantages when compared with its conventional form. In this context, this work describes the preparation and characterization of polyethylene glycol (PEG 4000) and its derivative particles loaded with benznidazole, as well as evaluates their trypanocidal activity. In this work, reactions to modify the PEG 4000 polymer and the subsequent incorporation of the benznidazole were made. The nuclear magnetic resonance (NMR) analysis confirmed the efficiency in modifying the PEG chains. The morphology of polymeric films was observed by atomic force microscopy (AFM) and showed considerable changes on the film organization. The acetylation of PEG favored the stability of the system and an increase in the zeta potential from -14.83 to -25.54 mV was observed. Although encapsulation efficiency values between 30.14 and 39.48% were found, the enhanced benznidazole dissolution profile by microparticles enables the use of lower drug concentrations. This fact can be proven by the increased trypanocidal effect of benznidazole when encapsulated in BP3 microparticles. Finally, the high selectivity of the formulations for trypanocidal action guarantees their safety as an alternative for the treatment of the Chagas disease.
local.identifier.orcidhttps://orcid.org/0000-0003-2408-3448
local.identifier.orcidhttps://orcid.org/0000-0002-6002-857X
local.identifier.orcidhttps://orcid.org/0000-0002-1807-971X
local.identifier.orcidhttps://orcid.org/0000-0003-0464-4754
local.identifier.orcidhttps://orcid.org/0000-0002-8523-2155
local.identifier.orcidhttps://orcid.org/0000-0002-0644-9197
local.identifier.orcidhttps://orcid.org/0000-0002-0888-5072
local.identifier.orcidhttps://orcid.org/0000-0002-6426-7113
local.identifier.orcidhttps://orcid.org/0000-0002-8904-6990
local.identifier.orcidhttps://orcid.org/0000-0002-6112-5574
local.identifier.orcidhttps://orcid.org/0000-0001-7033-7686
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://dx.doi.org/10.21577/0103-5053.20210017

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