Is there any association between toxoplasma gondii infection and bipolar disorder? a systematic review and meta-analysis

Página do item simplificado
dc.creatorJoão Luís Vieira Monteirode Barros
dc.creatorIzabela Guimarães Barbosa
dc.creatorHaitham Salem
dc.creatorNatalia Pessoa Rocha
dc.creatorArthur Melo e Kummer
dc.creatorOlaoluwa o. Okusaga
dc.creatorJair c. Soares
dc.creatorAntonio Lucio Teixeira
dc.date.accessioned2023-07-17T19:38:11Z
dc.date.accessioned2025-09-08T23:35:22Z
dc.date.available2023-07-17T19:38:11Z
dc.date.issued2017-11-17
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.jad.2016.11.016
dc.identifier.issn01650327
dc.identifier.urihttps://hdl.handle.net/1843/56475
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Affective Disorders
dc.rightsAcesso Restrito
dc.subjectTranstorno Bipolar
dc.subjectToxoplasma
dc.subject.otherBipolar disorder
dc.subject.otherToxoplasma gondii
dc.subject.otherImmunology
dc.subject.otherInflammation
dc.titleIs there any association between toxoplasma gondii infection and bipolar disorder? a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage65
local.citation.issue2017
local.citation.spage59
local.citation.volume209
local.description.resumoBackground: The relationship between Toxoplasma gondii infection and the development of bipolar disorder (BD) has long been investigated, yet to date it is still poorly understood and documented. The aim of this review is to derive a summary estimate of the strength of the association between infection with T. gondii and BD from the available published studies.Methods: A systematic review was performed using PubMed, LILACS, PsycINFO, and Embase databases.Studies which included a proportion of seropositive BD patients and controls were further examined in a metaanalysis.Results: One hundred eighteen citations were initially retrieved. Thirteen studies were included in our systematic review. Eight out of these thirteen studies were included in our meta-analysis. Statistical analyses showed that T. gondii infection is associated with with BD (OR=1.26).Limitations: Small sample size was the major limitation among the studies that carried out serological analyses.In addition, the available studies did not have enough information on disease status/severity or type of bipolar disorder. Also, it was not possible to analyze pregnancy status or perinatal infection. Future studies addressing the aforementioned topics are clearly needed.Conclusions: Despite heterogeneous results, patients with BD are more likely to be infected by T. gondii than controls. Early T. gondii infection might predispose the development of BD. T.gondii infection is becoming clinically relevant in psychiatric disorders and future mechanistic studies are required to elucidate the underlying pathophysiological mechanisms.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0165032716305614?via%3Dihub

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG