Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy

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dc.creatorEduardo Morato de Oliveira
dc.creatorRafael Soares Guieiro
dc.creatorBárbara Lima Cruz
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorJanine Mayra da Silva
dc.creatorTarcília Aparecida da Silva
dc.creatorPatrícia Carlos Caldeira
dc.date.accessioned2024-08-19T21:32:29Z
dc.date.accessioned2025-09-08T22:50:33Z
dc.date.available2024-08-19T21:32:29Z
dc.date.issued2021-06-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2021.vol35.0079
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/74279
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectSaliva
dc.subjectRadiotherapy
dc.subjectBone remodeling
dc.subjectBone remodeling
dc.subjectMouth neoplasms
dc.subjectHead and neck neoplasms
dc.subjectBiomarkers
dc.subjectReceptor activator of nuclear factor-kappa B
dc.subjectRANK ligand
dc.subjectOsteoprotegerin
dc.subjectOsteoprotegerin
dc.subjectMatrix Metalloproteinase 9
dc.subjectTissue inhibitor of Metalloproteinase-2
dc.subjectEndothelial growth factors
dc.subjectBlood
dc.subjectEpidermal growth factor
dc.subjectHomeostasis
dc.subjectMouth
dc.subject.otherSaliva
dc.titleSalivary molecules of bone remodeling and tissue repair after head and neck radiotherapy
dc.typeArtigo de periódico
local.citation.epagee86
local.citation.spagee79
local.citation.volume35 Brazilian Oral Research
local.description.resumoHead and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for head and neck cancer treatment, compared with non-irradiated individuals. Total unstimulated saliva was collected for ELISA assay analysis of receptor activator for nuclear factor κ B (RANK) and its ligand (RANK-L), osteoprotegerin, matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor, and epidermal growth factor. Statistics were performed, and revealed that salivary RANK (p = 0.0304), RANK-L (p = 0.0005), matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2 (p = 0.0067), vascular endothelial growth factor (p = 0.0060), and epidermal growth factor (p < 0.0001) were reduced in patients, compared with the control group. Osteoprotegerin did not differ between the groups (p = 0.3765). Salivary biomarkers did not differ according to radiotherapy completion time (p > 0.05). In conclusion, the lower output of the salivary molecules – essential for bone remodeling and tissue repair – may disrupt tissue homeostasis and play a role in the pathogenesis of the radiotherapy-induced deleterious effects in the oral cavity.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/bHKgmrxDGbmgsTKLykFQRdH/

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