Compressive non-toxic intrathoracic goiter in patient with contraindication to surgical treatment: case report

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dc.creatorGustavo Cancela e Penna
dc.creatorRachel Cardoso Lopes Rego
dc.creatorGabriela Malta Silva Diniz
dc.creatorGabriela Maciel Campolina Cardoso
dc.creatorRudolf Moreira Pfeilsticker
dc.creatorAdelina Sanches
dc.creatorBarbara Moreira Ribeiro Trindade dos Santos
dc.creatorHans Graf
dc.date.accessioned2023-11-27T19:37:19Z
dc.date.accessioned2025-09-09T01:24:12Z
dc.date.available2023-11-27T19:37:19Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.37871/jbres1429
dc.identifier.issn2766-2276
dc.identifier.urihttps://hdl.handle.net/1843/61410
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Biomedical Research and Environmental Sciences
dc.rightsAcesso Aberto
dc.subjectBócio
dc.subjectNódulo da glândula tireoide
dc.subjectTireoidectomia
dc.subject.otherGoiter
dc.subject.otherThyroid nodule
dc.titleCompressive non-toxic intrathoracic goiter in patient with contraindication to surgical treatment: case report
dc.typeArtigo de periódico
local.citation.epage245
local.citation.issue3
local.citation.spage240
local.citation.volume3
local.description.resumoIntroduction: Thyroidectomy is the treatment of choice for non-toxic compressive Multinodular Goiter (MNG). However, when surgery is contraindicated, other therapeutic options should be evaluated. In this case report, non-surgical therapeutic possibilities are reviewed, and the results obtained with Radioiodine Therapy (RAI) after stimulating with Recombinant Thyroid-Stimulating Hormone (rhTSH) are described. Case report: A 92-year-old patient with multiple comorbidities, non-toxic MNG, and symptomatic compression of the trachea and esophagus. Accordingly, RAI was chosen due to the high surgical risk. Initially, pre-treatment with methimazole was performed to increase TSH, which was interrupted due to drug hepatitis. Then, RAI was chosen in the post-stimulus with a low dose of rhTSH, with significant and early reduction of goiter and symptoms. Discussion: Although total thyroidectomy is the treatment of choice for non-toxic and symptomatic intrathoracic MNG; it does present risks, especially in patients with multiple comorbidities. Thus, interest in less invasive techniques is increasing. Thermal radio-ablations exhibit satisfactory results, however it is still an inaccessible technique. Radioiodine is an effective treatment option subsequent to the use of rhTSH or hypothyroidism methimazole-induced. RhTSH and methimazole can increase the level of radiation absorbed by the gland, which can lead to a reduction in the required I-131 dose. Conclusion: It is possible to mitigate the symptoms and improve the quality of life of patients with non-toxic and symptomatic MNG and multiple comorbidities, without surgical intervention. In this case report we describe alternatives to surgical intervention and show the effectiveness and safety of RAI along with rhTSH in the management of MNG.
local.identifier.orcidhttps://orcid.org/0000-0003-2125-7051
local.identifier.orcidhttps://orcid.org/0000-0002-4832-3955
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.jelsciences.com/articles/jbres1429.php

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