Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone

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dc.creatorTalita Bárbara Gontijo
dc.creatorRossimiriam Pereira de Freitas
dc.creatorGuilherme Ferreira de Lima
dc.creatorLucas Cunha Dias de Rezende
dc.creatorLeandro Ferreira Pedrosa
dc.creatorThaissa Lúcio Silva
dc.creatorMarilia Oliveira Fonseca Goulart
dc.creatorBruno Coêlho Cavalcanti
dc.creatorClaudia do Ó Pessoa
dc.creatorMarina Pereira Bruno
dc.creatorJosé Raimundo Corrêa
dc.creatorFlavio da Silva Emery
dc.creatorEufrânio Nunes da Silva Júnior
dc.date.accessioned2024-07-30T18:13:14Z
dc.date.accessioned2025-09-08T23:36:33Z
dc.date.available2024-07-30T18:13:14Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1039/C6CC07054J
dc.identifier.issn1364-548X
dc.identifier.urihttps://hdl.handle.net/1843/72112
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemical Communications
dc.rightsAcesso Aberto
dc.subjectQuinona
dc.subjectSíntese
dc.subjectRessonância magnética nuclear
dc.subjectEspectrometria de massa
dc.subjectEletroquímica
dc.subjectAgentes antineoplásicos
dc.subjectMicroscopia
dc.subjectSondas fluorescentes
dc.subject.otherBODIPY
dc.subject.otherSubcellular localisation
dc.subject.otherQuinone
dc.titleNovel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone
dc.typeArtigo de periódico
local.citation.epage13284
local.citation.issue90
local.citation.spage13281
local.citation.volume52
local.description.resumoFor the first time, a fluorescent lapachone-based BODIPY was synthesised and characterised by NMR and mass spectrometry. Computational and electrochemical aspects, as well as cytotoxic activity and subcellular localisation, were studied. Confocal microscopy experiments indicated that the probe was a specific mitochondria-staining agent. These in-detail analyses were useful in understanding the cytotoxic effects and mechanism of action of this novel hybrid compound. This molecule constitutes a promising prototype owing to its potential biological activities and the new strategies aimed at mechanistic investigations in cells and in vivo, and opens up an interesting avenue of research.
local.identifier.orcidhttps://orcid.org/0000-0002-7038-8560
local.identifier.orcidhttps://orcid.org/0000-0001-6974-3724
local.identifier.orcidhttps://orcid.org/0000-0002-0311-3831
local.identifier.orcidhttps://orcid.org/0000-0002-4095-3135
local.identifier.orcidhttps://orcid.org/0000-0002-2957-2307
local.identifier.orcidhttps://orcid.org/0000-0001-6557-8653
local.identifier.orcidhttps://orcid.org/0000-0001-9860-3667
local.identifier.orcidhttps://orcid.org/0000-0002-0725-8392
local.identifier.orcidhttps://orcid.org/0000-0002-4344-4336
local.identifier.orcidhttps://orcid.org/0000-0003-2752-5395
local.identifier.orcidhttps://orcid.org/0000-0002-8652-7123
local.identifier.orcidhttps://orcid.org/0000-0003-1281-5453
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc07054j

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