Efficient antibacterial nanosponges based on ZnO nanoparticles and doxycycline

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dc.creatorDiego Fernando Suárez Peñaranda
dc.creatorAna Paula de Figueiredo Monteiro
dc.creatorDaniele Cristina Ferreira
dc.creatorFrederico Dias Brandão
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorLuzia Valentina Modolo
dc.creatorMaría Esperanza Cortés Segura
dc.creatorRuben Dario Sinisterra Millán
dc.date.accessioned2022-11-03T13:34:55Z
dc.date.accessioned2025-09-08T23:59:09Z
dc.date.available2022-11-03T13:34:55Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttps://doi.org/10.1016/j.jphotobiol.2017.10.018
dc.identifier.issn10111344
dc.identifier.urihttps://hdl.handle.net/1843/46854
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Photochemistry and Photobiology B: Biology
dc.rightsAcesso Restrito
dc.subjectNanopartículas
dc.subject.otherNanoparticles
dc.subject.otherZnO nanoparticles
dc.subject.otherAntimicrobial nanoparticles
dc.titleEfficient antibacterial nanosponges based on ZnO nanoparticles and doxycycline
dc.typeArtigo de periódico
local.citation.epage94
local.citation.spage85
local.citation.volume177
local.description.resumoBacterial soft rot is responsible for the loss of about 25% of worldwide production in vegetables and fruits. Efforts have been made to develop an effective nanosponge with the capacity to load and release antibacterial drugs to protect plants. Based on the potential of the ZnO nanoparticles (ZnO–NPs) to achieve this goal, this study synthesized NP via the sol-gel and hydrothermal methods by controlling native defects, such as oxygen vacancies, using thermal treatments and reduced atmospheres. To characterize the ZnO NPs, X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), optical spectroscopy, electron paramagnetic resonance (EPR), Zeta Potential measurements and surface area with the Brunauer–Emmett–Teller (BET) method were used. The photophysical and photochemical properties via spin trapping method aligned with EPR using UVA light showed a greater formation of electron-hole pairs and hydroxyl radicals for the reduced ZnO NPs when compared with the oxidized ones. Additionally, we found that reduced ZnO-NPs have high effectively against Escherichia coli, Erwinia carotovora and Pantoea sp. bacteria using the photocatalytic effect in the UV range. Moreover, ZnO-NPs loaded with DOX release profile enables the release of DOX within 46 days, where 25% was released during the first 10 h followed by a second delivery phase with an interesting short-term efficacy (< 1 day) against E. carotovora and Pantoea sp. Bacteria. For the first time, it was demonstrated that ZnO-NPs and ZnO-NPs loaded with DOX have efficient UV photocatalytic activities against bacterial soft rot infections.
local.identifier.orcidhttps://orcid.org/0000-0002-3139-4239
local.identifier.orcidhttps://orcid.org/0000-0002-4202-1964
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0002-8033-0434
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S101113441730564X

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