Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome

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dc.creatorAdriana Teixeirarodrigues
dc.creatorLuiz Ronaldo Alberti
dc.creatorPriscila Menezes Ferri Liu
dc.creatorEleonora Druve Tavares Fagundes
dc.creatorThaís Costa Nascentes Queiroz
dc.creatorPamela de Souza Haueisen Barbosa
dc.creatorSoraya Luiza Campos Silva
dc.creatorAna Cristina Simões e Silva
dc.creatorDébora Marques Miranda
dc.creatorAlexandre Rodrigues Ferreira
dc.date.accessioned2023-07-28T22:13:27Z
dc.date.accessioned2025-09-09T00:59:11Z
dc.date.available2023-07-28T22:13:27Z
dc.date.issued2016-07
dc.format.mimetypepdf
dc.identifier.doi10.1097/mpg.0000000000001125
dc.identifier.issn02772116
dc.identifier.urihttps://hdl.handle.net/1843/57183
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.rightsAcesso Aberto
dc.subjectHepatite Autoimune
dc.subjectCriança
dc.subjectPrognóstico
dc.subject.otherAutoimmune hepatitis
dc.subject.otherChildren
dc.subject.otherOverlap syndrome
dc.subject.otherPrognostic
dc.titleClinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome
dc.typeArtigo de periódico
local.citation.epage81
local.citation.issue1
local.citation.spage76
local.citation.volume63
local.description.resumoObjectives: This is a cohort study of 134 children and adolescents with a known diagnosis of autoimmune hepatitis (AIH). During follow-up, some of them developed autoimmune sclerosing cholangitis (ASC). This study describes the characteristics of the patients upon diagnosis, and their response to treatment and any complications, and compares the patients who developed ASC during follow-up (ASC group) with those who did not (AIH group). Methods: A total of 73.1% of the patients were girls with a median age upon diagnosis of 10.41 (7.41–12.53) years. Results: Of 134 patients, 28 (20.9%) developed cholestatic manifestations, with features of ASC. A few differences were observed between the AIH and ASC groups when they were analyzed by x2 test, such as the smaller predominance of girls in ASC group (P ¼ 0.04), and more common asymptomatic presentation in the ASC group (P ¼ 0.01). Cirrhosis was observed in 68% of biopsies, with no significant difference between groups (P ¼ 0.43). Of 16 deaths, 15 were in the AIH group and 1 in the ASC group (P ¼ 0.22). Of 11 transplants, 10 were in the AIH group and one in the ASC group (P ¼ 0.53). The presence of cirrhosis at baseline was associated with a smaller survival probability (P ¼ 0.015). The survival rate by Kaplan-Meier method was 94% at 5 years and 80% at 10 years, and was similar in both the groups (P ¼ 0.08). Conclusions: No statistically significant difference was observed between the groups in relation to prognosis and response to treatment.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/jpgn/Fulltext/2016/07000/Clinical_Characteristics_and_Prognosis_in_Children.17.aspx

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