Apelin and visfatin expression in placental tissue in women with preeclampsia and overweight/obesity

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dc.creatorAna Paula dos Santos Xavier Braga
dc.creatorDiana Matos Silva
dc.creatorDeborah de Farias Lelis
dc.creatorRogério Estevam Farias
dc.creatorAlanna Fernandes Paraíso
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAndrea Maria Eleutério de Barros Lima Martins
dc.creatorJoão Marcus Oliveira Andrade
dc.date.accessioned2024-10-09T20:39:50Z
dc.date.accessioned2025-09-09T00:09:26Z
dc.date.available2024-10-09T20:39:50Z
dc.date.issued2023-05-28
dc.identifier.doihttps://doi.org/10.1177/109980042311788
dc.identifier.issn1552-4175
dc.identifier.urihttps://hdl.handle.net/1843/77346
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiological Research For Nursing
dc.rightsAcesso Restrito
dc.subjectPré-eclampsia
dc.subjectGravidez
dc.subjectHipertensão na gravidez
dc.subjectPlacenta
dc.subjectObesidade
dc.subjectCitocinas
dc.titleApelin and visfatin expression in placental tissue in women with preeclampsia and overweight/obesity
dc.typeArtigo de periódico
local.citation.epage663
local.citation.issue4
local.citation.spage505
local.citation.volume25
local.description.resumoBackground: preeclampsia (PE) is a multifunctional and multisystem disorder. Several factors favor the development of PE, including obesity. Cytokines are also expressed in the placenta, predisposing to local alterations that favor the development of distinct pathological processes, including PE. This study aimed to evaluate the apelin and visfatin mRNA expression in the placental tissue of women with preeclampsia and overweight/obesity and correlates with maternal and fetal variables. Methods: a cross-sectional analytical study was performed with 60 pregnant women and their newborns. Clinical, anthropometric, and laboratory variables were collected. Placental tissue samples were obtained, and the apelin and visfatin mRNA expression levels were assessed by qRT-PCR. Results: the main findings evidenced lower levels of apelin expression in overweight/obese women, accompanied by a negative correlation with BMI and pre-pregnancy weight; a higher expression of apelin was also observed in women with late PE and no personal history of PE. For visfatin levels, higher expression levels were observed in women with late PE and term delivery. Furthermore, a positive correlation was observed between visfatin levels and fetal anthropometric parameters, such as weight, length, and head circumference. Conclusion: apelin levels were less expressed in overweight/obese women. Apelin and visfatin levels were correlated/associated with maternal-fetal variables.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/full/10.1177/10998004231178835

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