Phytochemicals of Avocado Residues as Potential Acetylcholinesterase Inhibitors, Antioxidants, and Neuroprotective Agents

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dc.creatorGeisa Gabriela da Silva
dc.creatorLúcia Pinheiro Santos Pimenta
dc.creatorJúlio Onésio Ferreira Melo
dc.creatorHenrique de Oliveira Prata Mendonça
dc.creatorRodinei Augusti
dc.creatorJacqueline Aparecida Takahashi
dc.date.accessioned2023-10-18T20:55:15Z
dc.date.accessioned2025-09-09T00:14:44Z
dc.date.available2023-10-18T20:55:15Z
dc.date.issued2022-03-15
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/molecules27061892
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/1843/59661
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecules
dc.rightsAcesso Aberto
dc.subjectBiomassa
dc.subjectAlzheimer, Doença de
dc.subjectAbacate
dc.subject.otherAvocado biomass
dc.subject.otherAlzheimer’s disease
dc.subject.otherNeuroprotective effect
dc.subject.otherAvocado seed
dc.subject.otherAvocado peel
dc.subject.otherPaper spray mass spectrometry
dc.titlePhytochemicals of Avocado Residues as Potential Acetylcholinesterase Inhibitors, Antioxidants, and Neuroprotective Agents
dc.typeArtigo de periódico
local.citation.epage18
local.citation.issue6
local.citation.spage1892
local.citation.volume27
local.description.resumoAvocado (Persea americana) is a widely consumed fruit and a rich source of nutrients and phytochemicals. Its industrial processing generates peels and seeds which represent 30% of the fruit. Environmental issues related to these wastes are rapidly increasing and likely to double, according to expected avocado production. Therefore, this work aimed to evaluate the potential of hexane and ethanolic peel (PEL-H, PEL-ET) and seed (SED-H, SED-ET) extracts from avocado as sources of neuroprotective compounds. Minerals, total phenol (TPC), total flavonoid (TF), and lipid contents were determined by absorption spectroscopy and gas chromatography. In addition, phytochemicals were putatively identified by paper spray mass spectrometry (PSMS). The extracts were good sources of Ca, Mg, Fe, Zn, ω-6 linoleic acid, and flavonoids. Moreover, fifty-five metabolites were detected in the extracts, consisting mainly of phenolic acids, flavonoids, and alkaloids. The in vitro antioxidant capacity (FRAP and DPPH), acetylcholinesterase inhibition, and in vivo neuroprotective capacity were evaluated. PEL-ET was the best acetylcholinesterase inhibitor, with no significant difference (p > 0.05) compared to the control eserine, and it showed neither preventive nor regenerative effect in the neuroprotection assay. SED-ET demonstrated a significant protective effect compared to the control, suggesting neuroprotection against rotenone-induced neurological damage.
local.identifier.orcidhttps://orcid.org/0000-0002-5596-8698
local.identifier.orcidhttps://orcid.org/0000-0001-8384-6877
local.identifier.orcidhttps://orcid.org/0000-0002-7483-0942
local.identifier.orcidhttps://orcid.org/0000-0002-9448-9518
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1420-3049/27/6/1892

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