Systematic review and meta-analysis of outcomes in patients with suspected deep vein thrombosis

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dc.creatorPayal Patel
dc.creatorParth Patel
dc.creatorMeha Bhatt
dc.creatorCody Braun
dc.creatorHousne Begum
dc.creatorRobby Nieuwlaat
dc.creatorRohan Kehar
dc.creatorRasha Khatib
dc.creatorCarolina de Castro Martins
dc.creatorYuan Zhang
dc.creatorItziar Etxeandia-Ikobaltzeta
dc.creatorJamie Varghese
dc.creatorHani Alturkmani
dc.creatorWaled Bahaj
dc.creatorMariam Baig
dc.creatorRohan Kehar
dc.creatorAhmad Mustafa
dc.creatorRakesh Ponnapureddy
dc.creatorAnchal Sethi
dc.creatorMerrill Thomas
dc.creatorDavid Wooldridge
dc.creatorWendy Lim
dc.creatorShannon Bates
dc.creatorEddy Lang
dc.creatorGregoire Le Gal
dc.creatorMarc Righini
dc.creatorWojtek Wiercioch
dc.creatorHolger Schunemann
dc.creatorReem Mustafa
dc.date.accessioned2024-04-25T19:47:00Z
dc.date.accessioned2025-09-09T00:03:36Z
dc.date.available2024-04-25T19:47:00Z
dc.date.issued2020-06
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1182/bloodadvances.2020001558
dc.identifier.issn2473-9537
dc.identifier.urihttps://hdl.handle.net/1843/67730
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBlood Advances
dc.rightsAcesso Restrito
dc.subjectHealth services
dc.subjectOutcome and process assessment, health care
dc.subjectThrombosis
dc.subjectHemostasis
dc.subject.otherHealth services and outcomes
dc.subject.otherSystematic review
dc.subject.otherThrombosis and hemostasis
dc.titleSystematic review and meta-analysis of outcomes in patients with suspected deep vein thrombosis
dc.typeArtigo de periódico
local.citation.epage2788
local.citation.issue12
local.citation.spage2779
local.citation.volume4
local.description.resumoAfter deep vein thrombosis (DVT) is diagnosed, prompt evaluation and therapeutic intervention are of paramount importance for improvement in patient-important outcomes. We systematically reviewed patient-important outcomes in patients with suspected DVT, including mortality, incidence of pulmonary embolism (PE) and DVT, major bleeding, intracranial hemorrhage, and postthrombotic sequelae. We searched the Cochrane Central Register of Controlled Trials, Ovid Medline, Embase for eligible studies, references lists of relevant reviews, registered trials, and relevant conference proceedings. Two investigators screened and abstracted data. Nine studies with 5126 patients were included for lower extremity DVT. Three studies with 500 patients were included for upper extremity DVT. Among patients with lower extremity DVT, 0.85% (95% confidence interval [CI], 0% to 2.10%) and 0% developed recurrent DVT and PE, respectively, at 3 months. Among patients with upper extremity DVT, 0.49% (95% CI, 0% to 1.16%) and 1.98% (95% CI, 0.62% to 3.33%) developed recurrent DVT and PE, respectively, at 3 months. No major bleeding events were reported for those anticoagulated, which is lower than in other systematic reviews. For both upper and lower extremity DVT, low pretest probability patients with a negative D-dimer had a comparable incidence of VTE at 3 months (∼1%) as patients with a negative ultrasound (US). At higher pretest probabilities, negative US testing with or without serial US appears to be the safer option. In this review, we summarized the outcomes of patients evaluated by various diagnostic pathways. In most instances, there was significant limitation due to small population size or lack of direct evidence of effects of using a specific pathway. This systematic review was registered at PROSPERO as CRD42018100502.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://ashpublications.org/bloodadvances/article/4/12/2779/461054/Systematic-review-and-meta-analysis-of-outcomes-in

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