Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

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dc.creatorGabriel Perfeito Castro
dc.creatorDaniel de Castro Medeiros
dc.creatorLeonardo de Oliveira Guarnieri
dc.creatorFlávio Afonso Gonçalves Mourão
dc.creatorHyorrana Priscila Pereira Pinto
dc.creatorGrace Schenatto Pereira Moraes
dc.creatorMárcio Flávio Dutra Moraes
dc.date.accessioned2023-07-14T20:32:26Z
dc.date.accessioned2025-09-08T23:51:10Z
dc.date.available2023-07-14T20:32:26Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1016/j.yebeh.2015.08.039
dc.identifier.issn1525-5069
dc.identifier.urihttps://hdl.handle.net/1843/56297
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEpilepsy & Behavior
dc.rightsAcesso Aberto
dc.subjectEpilepsia
dc.subjectConvulsões
dc.subject.otherEpilepsy
dc.subject.otherSeizure predisposition
dc.subject.otherWistaraudiogenic rat
dc.subject.otherComorbidities
dc.subject.otherPsychiatric disorder
dc.titleWistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility
dc.typeArtigo de periódico
local.citation.epage249
local.citation.issuePart B
local.citation.spage243
local.citation.volume71
local.description.resumoAccumulating evidence from different animal models has contributed to the understanding of the bidirectional comorbidity associations between the epileptic condition and behavioral abnormalities. A strain of animals inbred to enhance seizure predisposition to high-intensity sound stimulation, the Wistar audiogenic rat (WAR), underwent several behavioral tests: forced swim test (FST), open-field test (OFT), sucrose preference test (SPT), elevated plus maze (EPM), social preference (SP), marble burying test (MBT), inhibitory avoidance (IAT), and two-way active avoidance (TWAA). The choice of tests aimed to investigate the correlation between underlying circuits believed to be participating in both WAR's innate susceptibility to sound-triggered seizures and the neurobiological substrates associated with test performance. Comparing WAR with its Wistar counterpart (i.e., resistant to audiogenic seizures) showed that WARs present behavioral despair traits (e.g., increased FST immobility) but no evidence of anhedonic behavior (e.g., increased sucrose consumption in SPT) or social impairment (e.g., no difference regarding juvenile exploration in SP). In addition, tests suggested that WARs are unable to properly evaluate degrees of aversiveness (e.g., performance on OFT, EPM, MBT, IAT, and TWAA). The particularities of the WAR model opens new venues to further untangle the neurobiology underlying the co-morbidity of behavioral disorders and epilepsy.
local.identifier.orcidhttps://orcid.org/0000-0003-0243-1309
local.identifier.orcidhttps://orcid.org/0000-0002-2566-2532
local.identifier.orcidhttps://orcid.org/0000-0002-4519-3585
local.identifier.orcidhttps://orcid.org/0000-0002-2513-1504
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1525505015005144?via%3Dihub

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