In vitro and in silico studies of antioxidant activity of 2-thiazolylhydrazone derivatives

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dc.creatorVinícius Gonçalves Maltarollo
dc.creatorMarina Ferrara de Resende
dc.creatorThales Kronenberger
dc.creatorCleudiomar Inácio Lino
dc.creatorMaria Clara Pinheiro Duarte Sampaio
dc.creatorMaira Galdino da Rocha Pitta
dc.creatorMoacyr Jesus Barreto de Melo Rêgo
dc.creatorRenata Adriana Labanca
dc.creatorRenata Barbosa de Oliveira
dc.date.accessioned2022-05-17T15:21:49Z
dc.date.accessioned2025-09-09T01:04:02Z
dc.date.available2022-05-17T15:21:49Z
dc.date.issued2019-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1016/j.jmgm.2018.10.007
dc.identifier.issn1093-3263
dc.identifier.urihttps://hdl.handle.net/1843/41756
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Molecular Graphics and Modelling
dc.rightsAcesso Restrito
dc.subjectTecnologia de alimentos
dc.subjectAtividade antioxidante
dc.subjectEstudos in vitro
dc.subjectEstudos in silico
dc.subject.otherAntioxidant activity
dc.subject.other2-Thiazolylhydrazone
dc.subject.otherChemometric
dc.subject.otherCytotoxic activity
dc.titleIn vitro and in silico studies of antioxidant activity of 2-thiazolylhydrazone derivatives
dc.typeArtigo de periódico
local.citation.epage112
local.citation.spage106
local.citation.volume86
local.description.resumoThe antioxidant potential of a series of thiazolylhydrazone derivatives was investigated using three different methods namely DPPH, ABTS and FRAP assays. In general, the tested compounds showed higher or comparable activity to that of curcumin, used as positive control. Chemometric analyses demonstrated that the presence of hydrazone moiety is required for the activity of this class of compounds. From these results, compound 4 was identified as the most promising molecule and was then selected for further studies. The antiproliferative effect of compound 4 was evaluated, being active in three (T47D, MDA-MB-231 and SKMEL) of the six cancer cell lines tested, with IC50 values ranging from 15.9 to 31.3 μM. Compound 4 exhibited no detectable cytotoxic effect on peripheral blood mononuclear cells (PBMC) when tested at a concentration of 100 μM, demonstrating good selectivity. From these results, it is possible to infer that there is a correlation between antioxidant capacity and anticancer effects.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1093326318304510?via%3Dihub

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