Azitromycin for chronic eosihophilic rhinosinusitis with nasal polyp: a placebo-controlled trial
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Background: Chronic eosinophilic rhinosinusitis with nasal polyps (CRSwNP eosinophilic) is characterised by the formation of
benign and bilateral nasal polyps. We aimed to compare the effectiveness of azithromycin as an immunomodulator with the use
of a placebo in patients presenting with CRSwNP concomitant with asthma and aspirin intolerance after 3 months of treatment
and at a 1-year follow-up.Methodology: We performed a randomised, double-blind, placebo-controlled trial. Patients received 500 mg azithromycin orally three times/week for 12 weeks. Improvement was evaluated by staging, the Sino-Nasal Outcome Test (SNOT-22), and nasal polyp biopsy. Data collected at pretreatment and 3 months posttreatment were compared. Quality of life was evaluated at the 1-year follow-up. Results: Twenty-seven and 21 patients were treated with azithromycin and a placebo, respectively. The medication was well tolerated overall. Twenty patients (74%) in the azithromycin group and three patients (14%) in the placebo group were not referred for surgery at the end of the 3-month treatment. Regarding subjective improvement, there was a median decrease only in the
azithromycin group, and the between-group difference was significant. SNOT-22 improvement was maintained in the azithromycin group at the 1-year follow-up. Conclusions: Azithromycin could be considered a therapeutic option for patients presenting with CRSwNP concomitant with asthma and aspirin intolerance.
Abstract
Assunto
Aspirina, Azitromicina, Endoscopia, Eosinófilos, Pólipos Nasais
Palavras-chave
Aspirin, Azithromycin, Endoscopy, Eosinophils, Nasal polyposis
Citação
Curso
Endereço externo
https://www.rhinologyjournal.com/Abstract.php?id=2662