Adverse drug reactions to thalidomide in hansen’s disease patients
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de evento
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Background: In Brazil, thalidomide (TLD) is the firstline treatment for Erythema Nodosum Leprosum
(ENL) in patients with Hansen’s disease. The lack of
information concerning adverse drug reactions
(ADR) related to TLD and the incipient surveillance
has motivated this study.
Objectives: To estimate the frequency of ADR
associated with TLD use in patients with ENL. In
addition, issues related to prescription, dispensing
and pharmacovigilance activities of TLD were
evaluated.
Methods: Cross-sectional study involving patients
attending dermatologic clinics of a public referral
hospital for infectious diseases in Minas Gerais State,
Brazil. All patients (≥18 years) using TLD for ENL
between July and October 2016 were invited to
participate in the study. Patients were interviewed
and asked to respond to questions about sociodemographic variables, variables related to their health
state, understanding of TLD treatment, accordance
with national regulatory law, and ADR experienced
during the treatment.
Results: A total of 110 patients were interviewed.
Most were men (65.5%) aged on average 47.8 years
old. The mean length of TLD use was 37.3 months.
Twenty-three out of 38 women reported the use of
injectable medroxyprogesterone, 16.7% had been submitted to a previous sterilization procedure, 19.4%
were not in fertile age, and 33.7% of patients referred
condom use. Approximately 80.0% of the patients
knew they used TLD for ENL or Hansen’s disease
whereas 19.3% were not aware about the reason of
TLD’s use. Most ADR comprised dry skin (94.6%),
paresthesia (82.7%), somnolence (77.3%), weight
gain (66.4%), tremor (60.9%), adynamia (60.0%),
pain (52.7%), dry mouth (52.7%), anxiety (52.7%),
impotence (25.5%), lower limb edema (20.9%) and
thrombosis (6.4%).
Conclusions: ADR were very common among TLD
patients. Women in fertile age are under contraceptive
use to ensure birth control, but not all patients reported
the use of condom. Apparently, most patients understand the need of TLD and perceive the main adverse
effects.
Abstract
Assunto
Reações adversas a medicamentos, Hanseníase
Palavras-chave
Reações adversas a medicamentos, Talidomida, Hanseníase
Citação
Departamento
Curso
Endereço externo
https://onlinelibrary.wiley.com/doi/full/10.1002/pds.4275