Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?

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dc.creatorSilene Barbieri
dc.creatorLauren Frenzel Schuch
dc.creatorAndreia Morales Cascaes
dc.creatorAna Paula Neutzling Gomes
dc.creatorSandra Beatriz Chaves Tarquinio
dc.creatorRicardo Alves de Mesquita
dc.creatorAna Carolina Uchoa Vasconcelos
dc.creatorAdriana Etges
dc.date.accessioned2024-11-05T20:12:56Z
dc.date.accessioned2025-09-08T23:07:55Z
dc.date.available2024-11-05T20:12:56Z
dc.date.issued2022-03-14
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2022.vol36.0044
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/77835
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectDendritic cells
dc.subjectMouth neoplasms
dc.subjectImmune system
dc.subjectCorrelation of data
dc.subjectCarcinoma, squamous cell
dc.subjectSmokers
dc.subjectTongue
dc.subjectGingiva
dc.subjectImmunohistochemistry
dc.subject.otherDendritic cells
dc.subject.otherMouth neoplasms
dc.subject.otherTabacco
dc.subject.otherImmune system
dc.titleDoes smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
dc.typeArtigo de periódico
local.citation.epage7
local.citation.spage1
local.citation.volume36
local.description.resumoThe aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma.
local.identifier.orcidhttps://orcid.org/0000-0002-5265-3519
local.identifier.orcidhttps://orcid.org/0000-0002-0993-936X
local.identifier.orcidhttps://orcid.org/0000-0001-9412-8299
local.identifier.orcidhttps://orcid.org/0000-0003-2214-5246
local.identifier.orcidhttps://orcid.org/0000-0003-1496-4137
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0001-6560-9536
local.identifier.orcidhttps://orcid.org/0000-0002-6066-869X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/ynspQHLbnq3Wg6ptMWhWDBP/#:~:text=Smoking%20changes%20the%20oral%20immune%20system%20and%20decreases,development%20and%20progression%20of%20oral%20squamous%20cell%20carcinoma.

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