Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol

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dc.creatorFernando César Silva
dc.creatorVanessa Gregório Rodrigues
dc.creatorLucienir Pains Duarte
dc.creatorIvana Silva Lula
dc.creatorRubén Dario Sinisterra Millán
dc.creatorSidney Augusto Vieira Filho
dc.creatorRodrigo Araújo Lima Rodrigues
dc.creatorErna Geessien Kroon
dc.creatorPatrícia Luciana de Oliveira
dc.creatorLuiz de Macêdo Farias
dc.creatorPaula Prazeres Magalhães
dc.creatorGrácia Divina de Fátima Silva
dc.date.accessioned2023-11-22T14:58:50Z
dc.date.accessioned2025-09-09T00:07:11Z
dc.date.available2023-11-22T14:58:50Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/0001-3765201720160046
dc.identifier.issn1678-2690
dc.identifier.urihttps://hdl.handle.net/1843/61251
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnais da Academia Brasileira de Ciências
dc.rightsAcesso Aberto
dc.subjectQuímica vegetal
dc.subjectAgentes antivirais
dc.subjectAgentes antibacterianos
dc.subjectDengue
dc.subjectDiarréia
dc.subjectMaytenus
dc.subjectCiclodextrinas
dc.subjectRessonância magnética nuclear
dc.subject.otherAntidiarrheal
dc.subject.otherCelastraceae
dc.subject.otherPentacyclic triterpene
dc.subject.otherAntiviral activity
dc.titleAntidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol
dc.typeArtigo de periódico
local.citation.epage1564
local.citation.issue3
local.citation.spage1555
local.citation.volume89
local.description.resumoDiarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising.
local.identifier.orcidhttps://orcid.org/0000-0002-8593-3090
local.identifier.orcidhttps://orcid.org/0000-0002-8885-6625
local.identifier.orcidhttps://orcid.org/0009-0006-3987-5738
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0002-8171-8035
local.identifier.orcidhttps://orcid.org/0000-0001-7148-4012
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0002-7462-767X
local.identifier.orcidhttps://orcid.org/0000-0001-6519-8490
local.publisher.countryBrasil
local.publisher.departmentFAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINO
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aabc/a/wjtnZBLw8hDT9WWf5rh5QcC/

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