Basal cells show increased expression of aromatase and estrogen receptor α in prostate epithelial lesions of male aging rats

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dc.creatorMônica Morais Santos
dc.creatorHipácia Werneck Gomes
dc.creatorGabriel Henrique Campolina Silva
dc.creatorLeticia C. Santos
dc.creatorGermán A. B. Mahecha
dc.creatorRex Hess
dc.creatorCleida Aparecida de Oliveira
dc.date.accessioned2023-07-14T20:23:01Z
dc.date.accessioned2025-09-08T23:32:18Z
dc.date.available2023-07-14T20:23:01Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1210/en.2017-00773
dc.identifier.issn0013-7227
dc.identifier.urihttps://hdl.handle.net/1843/56282
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEndocrinology
dc.rightsAcesso Aberto
dc.subjectProstata
dc.subjectEnvelhecimento
dc.subject.otherProstate
dc.subject.otherEstrogen receptor
dc.subject.otherAromatase
dc.subject.otherAging
dc.subject.otherBasal cell
dc.titleBasal cells show increased expression of aromatase and estrogen receptor α in prostate epithelial lesions of male aging rats
dc.typeArtigo de periódico
local.citation.epage732
local.citation.issue2
local.citation.spage723
local.citation.volume159
local.description.resumoBesides androgens, estrogen signaling plays a key role in normal development and pathologies of the prostate. Irreversible synthesis of estrogens from androgens is catalyzed by aromatase. Interestingly, animals lacking aromatase do not develop cancer or prostatitis, whereas those with overexpression of aromatase and, consequently, high estrogen levels develop prostatitis and squamous metaplasia via estrogen receptor 1 (ERα). Even with this evidence, the aromatase expression in the prostate is controversial. Moreover, little is known about the occurrence of age-dependent variation of aromatase and its association with histopathological changes commonly found in advanced age, a knowledge gap that is addressed herein. For this purpose, the immunoexpression of aromatase was evaluated in the prostatic complex of young adult to senile Wistar rats. ERα was also investigated, to extend our understanding of estrogen responsiveness in the prostate. Moderate cytoplasmic immunoreactivity for aromatase was detected in the glandular epithelium. Eventually, some basal cells showed intense staining for aromatase. The expression pattern for aromatase appeared similar in the normal epithelium when young and senile rats were compared; this result was corroborated by Western blotting. Conversely, in senile rats, there was an increase in the frequency of basal cells intensely stained for aromatase, which appeared concentrated in areas of intraepithelial proliferation and prostatitis. These punctual areas also presented increased ERα positivity. Together, these findings suggest a plausible source for hormonal imbalance favoring estrogen production, which, by acting through ERα, may favor the development of prostatic lesions commonly found in advanced age.
local.identifier.orcidhttps://orcid.org/0000-0001-5157-159X
local.identifier.orcidhttps://orcid.org/0000-0001-5243-8272
local.identifier.orcidhttps://orcid.org/0000-0002-4473-3340
local.identifier.orcidhttps://orcid.org/0000-0003-2907-0945
local.identifier.orcidhttps://orcid.org/0000-0003-2649-3563
local.identifier.orcidhttps://orcid.org/0000-0001-9610-7846
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/endo/article/159/2/723/4600203

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