Sulfonamide-functionalized polymeric nanoparticles for enhanced in vivo colorectal cancer therapy

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dc.creatorPedro Pires Goulart Guimarães
dc.creatorCelso Tarso Rodrigues Viana
dc.creatorLuciana Xavier Pereira
dc.creatorSávio Morato Lacerda Gontijo
dc.creatorPaula Peixoto Campos
dc.creatorSilvia Passos Andrade
dc.creatorRobson Augusto Souza dos Santos
dc.creatorRubén Dario Sinisterra Millán
dc.date.accessioned2024-01-29T13:42:20Z
dc.date.accessioned2025-09-08T22:58:47Z
dc.date.available2024-01-29T13:42:20Z
dc.date.issued2022
dc.identifier.doihttps://doi.org/10.2174/1567201818666210729110127
dc.identifier.issn1875-5704
dc.identifier.urihttps://hdl.handle.net/1843/63455
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Drug Delivery
dc.rightsAcesso Restrito
dc.subjectNanopartículas
dc.subjectCâncer - Tratamento
dc.subjectCólon (Anatomia) - Câncer
dc.subjectSistema de distribuição de medicamentos
dc.subjectSistemas deliberados de drogas poliméricas
dc.subjectÁcidos sulfônicos
dc.subject.otherPLGA
dc.subject.otherPolymeric nanoparticles
dc.subject.otherSulfonamide
dc.subject.otherDrug delivery
dc.subject.otherColorectal cancer
dc.subject.otherCancer therapy
dc.titleSulfonamide-functionalized polymeric nanoparticles for enhanced in vivo colorectal cancer therapy
dc.typeArtigo de periódico
local.citation.epage685
local.citation.issue6
local.citation.spage676
local.citation.volume19
local.description.resumoBackground: Colorectal cancer (CRC) is the third most common cancer in the world. 5- Fluorouracil (5-FU) is a conventional and most effective drug used in the clinic for the treatment of CRC. However, the clinical use of 5-FU is limited due to the acquired resistance and systemic toxicity, such as hepatotoxicity and gastrointestinal toxicity. Objective: Recent advances in nanomedicine are being exploited to develop nanoparticle platforms to overcome resistance and therapeutic delivery of active molecules. Here, we developed 5-FU loaded sulfadiazine-poly(lactide-co-glycolide) nanoparticles (SUL-PLGA NPs) to be applied in the colorectal cancer model. Methods: We assessed the in vivo efficacy of the SUL-PLGA NPs to enhance the antitumor effect of 5-FU. Results: In vivo treatment with 5-FU-SUL-PLGA NPs significantly reduced tumor growth in a colon cancer xenograft model compared to free 5-FU and 5-FU loaded non-targeted NPs. Treatment with 5-FU-SUL-PLGA NPs also increased blood vessel diameters within tumors, which could act in conjunction to enhance antitumor efficacy. In addition, 5-FU-SUL-PLGA NPs significantly reduced liver mass and lung mass, which are the most common metastasis sites of CRC, and decreased liver hepatotoxicity compared to free 5-FU drug and 5-FU loaded non-targeted NPs. Conclusion: Our findings suggest that the use of 5-FU-SUL-PLGA NPs is a promising strategy to enhance 5-FU efficacy against CRC.
local.identifier.orcidhttps://orcid.org/0000-0003-4534-2779
local.identifier.orcidhttps://orcid.org/0000-0002-9407-3870
local.identifier.orcidhttps://orcid.org/0000-0002-7803-4345
local.identifier.orcidhttps://orcid.org/0000-0003-2016-2210
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/116952

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