Increased insulin sensitivity in individuals with neurofibromatosis type 1.

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dc.creatoras Martins
dc.creatorak Jansen
dc.creatorcm Matos
dc.creatorLuiz Oswaldo Rodrigues
dc.creatorDébora Marques de Miranda
dc.creatorNilton Rezende Alves
dc.date.accessioned2023-11-10T20:33:50Z
dc.date.accessioned2025-09-09T01:20:20Z
dc.date.available2023-11-10T20:33:50Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doidoi.org/10.20945/2359-3997000000007
dc.identifier.issn29694637
dc.identifier.urihttps://hdl.handle.net/1843/60801
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsAcesso Aberto
dc.subjectBlood Glucose
dc.subjectNeurofibromatosis 1
dc.subjectDiabetes Mellitus
dc.subjectInsulin Resistance
dc.subject.otherBlood Glucose
dc.subject.otherNeurofibromatosis 1
dc.subject.otherDiabetes Mellitus
dc.subject.otherInsulin Resistance
dc.titleIncreased insulin sensitivity in individuals with neurofibromatosis type 1.
dc.title.alternativeESTIMULAÇÃO TRANSCRANIANA POR CORRENTE CONTÍNUA (ETCC) E ASSIMETRIAS MANUAIS: O EFEITO DA ESTIMULAÇÃO NA DESTREZA MANUAL
dc.typeArtigo de periódico
local.citation.epage46
local.citation.issue1
local.citation.spage41
local.citation.volume62
local.description.resumoObjects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.20945/2359-3997000000007

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