Bedside echocardiography to predict mortality of covid-19 patients beyond clinical data: data from the provar-covid study

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dc.creatorSander Luis Gomes Pimentel
dc.creatorRodrigo Tavares Lanna Rocha
dc.creatorRenan Mello Oliveira
dc.creatorMárcia de Melo Barbosa
dc.creatorCraig Sable
dc.creatorAntonio Luiz Pinho Ribeiro
dc.creatorAndrea Zawacki Beaton
dc.creatorMaria Carmo Pereira Nunes
dc.creatorBruno Ramos Nascimento
dc.creatorJuliane Franco
dc.creatorKaciane Krauss Bruno Oliveira
dc.creatorClara Leal Fraga
dc.creatorFrederico Vargas Botinha de Macedo
dc.creatorLeonardo Arruda de Moraes Raso
dc.creatorRenata Eliane de Ávila
dc.creatorLuiza Pereira Afonso Dos Santos
dc.date.accessioned2024-01-09T19:37:45Z
dc.date.accessioned2025-09-09T01:04:06Z
dc.date.available2024-01-09T19:37:45Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doi10.1590/0037-8682-0382-2021
dc.identifier.issn16789849
dc.identifier.urihttps://hdl.handle.net/1843/62522
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.rightsAcesso Aberto
dc.subjectCOVID-19
dc.subjectEchocardiography
dc.subjectPrognosis
dc.subjectSARS-CoV-2
dc.subjectMortality
dc.subject.otherCOVID-19
dc.subject.otherEchocardiography
dc.subject.otherPrognosis
dc.subject.otherSARS-CoV-2
dc.subject.otherMortality
dc.titleBedside echocardiography to predict mortality of covid-19 patients beyond clinical data: data from the provar-covid study
dc.typeArtigo de periódico
local.citation.epage9
local.citation.issue(e0382-2021
local.citation.spage1
local.citation.volume54
local.description.resumoIntroduction: Cardiac involvement seems to impact prognosis of COVID-19, being more frequent in critically ill patients. We aimed to assess the prognostic value of right ventricular (RV) and left ventricular (LV) dysfunction, evaluated by bedside echocardiography (echo), in patients hospitalized with COVID-19. Methods: Patients admitted in 2 reference hospitals in Brazil from Jul to Sept/2020 with confirmed COVID-19 and moderate/severe presentations underwent clinical and laboratory evaluation, and focused bedside echo (GE Vivid-IQ), at the earliest convenience, with remote interpretation. The association between demographics, clinical comorbidities and echo variables with all-cause hospital mortality was assessed, and factors significant at p<0.10 were put into multivariable models. Results: Total 163 patients were enrolled, 59% were men, mean age 64±16 years, and 107 (66%) were admitted to intensive care. Comorbidities were present in 144 (88%) patients: hypertension 115 (71%), diabetes 61 (37%) and heart failure 22 (14%). In-hospital mortality was 34% (N=56). In univariate analysis, echo variables significantly associated with death were: LV ejection fraction (LVEF, OR=0.94), RV fractional area change (OR=0.96), tricuspid annular plane systolic excursion (TAPSE, OR=0.83) and RV dysfunction (OR=5.3). In multivariate analysis, after adjustment for clinical and demographic variables, independent predictors of mortality were age≥63 years (OR=5.53, 95%CI 1.52–20.17), LVEF<64% (OR=7.37, 95%CI 2.10–25.94) and TAPSE<18.5 mm (OR=9.43, 95% CI 2.57–35.03), and the final model had good discrimination, with C-statistic=0.83 (95%CI 0.75–0.91). Conclusion: Markers of RV and LV dysfunction assessed by bedside echo are independent predictors of mortality in hospitalized COVID-19 patients, after adjustment for clinical variables.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/0037-8682-0382-2021

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