The influence of splenic tissue on the survival and tcd4 and tcd8 lymphocyte rates in rats subjected to fecal peritonitis induction

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dc.creatorAndrea Saade Daher Borjaili
dc.creatorDanilo Nagib Salomão Paulo
dc.creatorTarcizo Afonso Nunes
dc.creatorGiseli Celestino Nunes
dc.creatorJulia Belizário Silveira
dc.creatorFlávia Heiderich Dall'orto
dc.creatorGabriel Souza Lorenzoni
dc.creatorMatheus Eduardo Daher Borjaili
dc.creatorBianca Prandi Campagnaro
dc.creatorMaressa Cristiane Malini de Lima
dc.creatorMarcela Souza Lima Paulo
dc.date.accessioned2024-01-19T18:44:23Z
dc.date.accessioned2025-09-09T01:32:04Z
dc.date.available2024-01-19T18:44:23Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/s0102-865020200100000003
dc.identifier.issn01028650
dc.identifier.urihttps://hdl.handle.net/1843/63156
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Cirúrgica Brasileira
dc.rightsAcesso Aberto
dc.subjectSplenectomy
dc.subjectPeritonitis
dc.subjectSpleen
dc.subjectImmunophenotyping
dc.subjectSurvival Rate
dc.subjectRats
dc.subject.otherSplenectomy
dc.subject.otherSpleen
dc.subject.otherPeritonitis
dc.subject.otherImmunophenotyping
dc.subject.otherSurvival Rate
dc.subject.otherRats
dc.titleThe influence of splenic tissue on the survival and tcd4 and tcd8 lymphocyte rates in rats subjected to fecal peritonitis induction
dc.typeArtigo de periódico
local.citation.issue1
local.citation.spage7
local.citation.volume35
local.description.resumoPurpose: Comparing survival rates of rats subjected to spleen procedures after fecal peritonitis induction. Assessing changes in TCD4 and CD8 lymphocyte rates before and after the procedures. Correlating animal survival with CD4 and CD8 lymphocytes. Methods: Thirty male Wistar rats were distributed into 3 groups of ten: spleen manipulation (SM); total splenectomy (TS); subtotal splenectomy with preservation of the inferior pole (IP). Rats were subjected to surgical procedure depending on the group. Seven days after surgery they underwent induction of peritonitis and survival time was recorded. All animals were subjected to two blood collections: before surgery and 70 days after it for TCD4/TCD8 lymphocyte counting. Results: Mean survival time was longer in the IP and SM groups and shorter in the TS group; there was significant difference between them. The comparison of the median number of CD4 did not present changes, whereas the comparison of the median number of CD8 decreased in the SM and IP groups. The correlation between the median number of TCD4 and TCD8 lymphocytes and the animals’ survival was not significant. Conclusion: The maintenance of splenic tissue contributed to increase the survival of rats and there was a change in the number of TCD8 lymphocytes
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/s0102-865020200100000003

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