A UBI 31-38 peptide-coumarin conjugate: photophysical features, imaging tracking and synergism with Amphotericin B against Cryptococcus

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dc.creatorSoraya Maria Zandim Maciel Dias Ferreira
dc.creatorHellem Cristina Silva Carneiro
dc.creatorRosemeire Brondi Alves
dc.creatorAna Carolina Silva Batista
dc.creatorEufrânio Nunes da Silva Júnior
dc.creatorGleiston Gonçalves Dias
dc.creatorJarbas Magalhães Resende
dc.creatorDaniel de Assis Santos
dc.creatorDébora L. Oliveira
dc.creatorMarcio Lourenço Rodrigues
dc.creatorRossimiriam Pereira de Freitas
dc.date.accessioned2024-07-16T17:26:18Z
dc.date.accessioned2025-09-09T00:31:36Z
dc.date.available2024-07-16T17:26:18Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.format.mimetypepdf
dc.identifier.doihttp://dx.doi.org/10.2174/1568026618666180221113137
dc.identifier.issn1873-4294
dc.identifier.urihttps://hdl.handle.net/1843/70779
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Topics in Medicinal Chemistry
dc.rightsAcesso Restrito
dc.subjectQuímica farmacêutica
dc.subjectMicroscopia
dc.subjectSistemas de varredura
dc.subjectAnfotericina B
dc.subjectAtividade antifúngica
dc.subject.otherUBI 31-38
dc.subject.otherPeptide-coumarin conjugate
dc.subject.otherFluorescent
dc.subject.otherAnticryptococcal activity
dc.subject.otherInteraction studies
dc.subject.otherConfocal scanning
dc.subject.otherLaser microscopy
dc.titleA UBI 31-38 peptide-coumarin conjugate: photophysical features, imaging tracking and synergism with Amphotericin B against Cryptococcus
dc.typeArtigo de periódico
local.citation.epage163
local.citation.issue2
local.citation.spage157
local.citation.volume18
local.description.resumoCryptococcosis is a fungal disease of global significance for which new effective treatments are needed. The conjugation of the synthetic antimicrobial peptide fragment UBI 31-38 to a coumarin derivative showed to be an effective approach for the design of a novel anticryptococcal agent. In addition to antifungal activity, the conjugate exhibited intense fluorescence, which could be valuable for mechanistic investigations of this molecule. In this work, we studied the photophysical properties of the conjugate and confocal scanning laser microscopy was used to inspect the distribution of the peptide-coumarin conjugate in Cryptococcus cell. The synergism of this compound with amphotericin B or fluconazole against C. gattii and C. neoformans strains was also investigated. The results indicated that the fluorescent conjugate alone as well as its combination with amphotericin B are promising tools against cryptococcosis.
local.identifier.orcidhttps://orcid.org/0000-0002-9981-6311
local.identifier.orcidhttps://orcid.org/0000-0001-9675-6889
local.identifier.orcidhttps://orcid.org/0000-0003-0546-2549
local.identifier.orcidhttps://orcid.org/0009-0008-2037-0494
local.identifier.orcidhttps://orcid.org/0000-0003-1281-5453
local.identifier.orcidhttps://orcid.org/0000-0003-4952-756X
local.identifier.orcidhttps://orcid.org/0000-0001-9827-7312
local.identifier.orcidhttps://orcid.org/0000-0002-1108-5666
local.identifier.orcidhttps://orcid.org/0000-0002-6081-3439
local.identifier.orcidhttps://orcid.org/0000-0001-6974-3724
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/88696

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