Atrazine affects the morphophysiology, tissue homeostasis and aromatase expression in the efferent ductules of adult rats with mild alterations in the ventral prostate

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dc.creatorElisângela Martins-Santos
dc.creatorCristiano Guimarães Pimenta
dc.creatorPollyana Rabelo Nunes Campos
dc.creatorAndré Gustavo Oliveira
dc.creatorGermán Arturo Bohórquez Mahecha
dc.creatorCleida Aparecida Oliveira
dc.date.accessioned2024-08-02T20:24:11Z
dc.date.accessioned2025-09-08T23:30:05Z
dc.date.available2024-08-02T20:24:11Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.chemosphere.2017.11.124
dc.identifier.issn0045-6535
dc.identifier.urihttps://hdl.handle.net/1843/72482
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemosphere
dc.rightsAcesso Aberto
dc.subjectAtrazina
dc.subjectAromatase
dc.subjectDisruptores Endócrinos
dc.subjectPróstata
dc.subjectHomeostase
dc.subject.otherAtrazine
dc.subject.otheraromatase
dc.subject.otherEfferent ductules
dc.subject.otherendocrine disruptor
dc.titleAtrazine affects the morphophysiology, tissue homeostasis and aromatase expression in the efferent ductules of adult rats with mild alterations in the ventral prostate
dc.typeArtigo de periódico
local.citation.epage967
local.citation.spage958
local.citation.volume193
local.description.resumoThe widely used herbicide atrazine is a potent endocrine disruptor known to cause increased aromatase expression and transient increase in testicular weight followed by remarkable testis atrophy. However, whether the effects of atrazine on the testes are primary or secondary to dysfunctions in other components of male reproductive tract remains unknown. Given the high sensitivity of the efferent ductules to estrogen imbalance and the similarity to alterations previously described for other disruptors of these ductules function, and the testicular alterations observed after atrazine exposure, we hypothesized that the efferent ductules could be a target for atrazine. Herein we characterized the efferent ductules and the ventral prostate of adult Wistar rats treated with 200 mg/kg/day of atrazine for 7, 15, and 40 days. Additionally, we evaluated if the effects of atrazine in these organs could be reduced after discontinuation of the treatment. Atrazine exposure resulted in mild effects on the ventral prostate, but remarkable alterations on the efferent ductules, including luminal dilation, reduced epithelial height, and disruption of the epithelial homeostasis, which coincides with increased aromatase expression. Together with our previous data, these results suggest that at least part of the testicular effects of atrazine may be secondary to the alterations in the efferent ductules.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0045653517319008

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