Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice

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dc.creatorLeandro Ceotto Freitas Lima
dc.creatorSoraya Wilke Saliba
dc.creatorJoão Marcus de Oliveira Andrade
dc.creatorMaria Luísa Cunha
dc.creatorPuebla Cassini-Vieira
dc.creatorJohn David Feltenberger
dc.creatorLucíola da Silva Barcelos
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Mauricio Batista de Paula
dc.creatorAntônio Carlos Pinheiro de Oliveira
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2022-08-15T13:12:23Z
dc.date.accessioned2025-09-09T01:22:45Z
dc.date.available2022-08-15T13:12:23Z
dc.date.issued2016-05-16
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipOutra Agência
dc.identifier.doi10.1007/s12035-016-9927-x
dc.identifier.issn1559-1182
dc.identifier.urihttps://hdl.handle.net/1843/44256
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecular Neurobiology
dc.rightsAcesso Aberto
dc.subjectDegeneração (Patologia)
dc.subjectSíndrome metabólica
dc.subjectObesidade
dc.titleNeurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice
dc.typeArtigo de periódico
local.citation.epage3475
local.citation.spage3465
local.citation.volume54
local.description.resumoDifferent factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal survival and MS, which opens the possibility of new pharmacological targets. This study investigates the influence of sirtuin metabolic pathways by examining the functional capacities of glucose-induced obesity in an excitotoxic state induced by a quinolinic acid (QA) animal model. Mice were divided into two groups that received different diets for 8 weeks: one group received a regular diet, and the other group received a high-fat diet (HF) to induce MS. The animals were submitted to a stereotaxic surgery and subdivided into four groups: Standard (ST), Standard-QA (ST-QA), HF and HF-QA. The QA groups were given a 250 nL quinolinic acid injection in the right striatum and PBS was injected in the other groups. Obese mice presented with a weight gain of 40 % more than the ST group beyond acquiring an insulin resistance. QA induced motor impairment and neurodegeneration in both ST-QA and HF-QA, although no difference was observed between these groups. The HF-QA group showed a reduction in adiposity when compared with the groups that received PBS. Therefore, the HF-QA group demonstrated a commitment-dependent metabolic pathway. The results suggest that an obesogenic diet does not aggravate the neurodegeneration induced by QA. However, the excitotoxicity induced by QA promotes a sirtuin pathway impairment that contributes to metabolic changes.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12035-016-9927-x

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