Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays

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dc.creatorIsabelle Pinto
dc.creatorGustavo Henrique Bianco de Souza
dc.creatorWalison Arthuso Vasconcellos
dc.creatorPaula Vieira
dc.creatorÂngela Andrade
dc.creatorJanaína Seibert
dc.creatorLuciano Pinto
dc.creatorVagner Santos
dc.creatorRafaela de Sousa
dc.creatorLucas Sousa
dc.creatorTatiane Amparo
dc.creatorViviane dos Santos
dc.creatorAndrea do Nascimento
dc.date.accessioned2023-04-25T20:40:01Z
dc.date.accessioned2025-09-09T00:27:26Z
dc.date.available2023-04-25T20:40:01Z
dc.date.issued2020-12-18
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-020-79257-3
dc.identifier.issn20452322
dc.identifier.urihttps://hdl.handle.net/1843/52485
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectPharmaceutical preparations
dc.subjectFlavonoids
dc.titlePreparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
dc.typeArtigo de periódico
local.citation.epage13
local.citation.issue1
local.citation.spage01
local.citation.volume10
local.description.resumoPlants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC-QTOF-MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the Mt/M∞ relatively to [Formula: see text], at a diffusion coefficient of 1.406 × 10-6 cm2 s-1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not differ significantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fibroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://pubmed.ncbi.nlm.nih.gov/33339861/

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