Aerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues

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dc.creatorLetícia Maria de Souza Cordeiro
dc.creatorÉrica Guilhen Mario
dc.creatorCarolina Campos Lima Moreira
dc.creatorAngélica Heringer Rodrigues
dc.creatorSamuel Penna Wanner
dc.creatorDanusa Dias Soares
dc.creatorLeida Maria Botion
dc.creatorAdaliene Versiani Matos Ferreira
dc.date.accessioned2022-06-02T18:08:07Z
dc.date.accessioned2025-09-09T01:18:18Z
dc.date.available2022-06-02T18:08:07Z
dc.date.issued2019-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/jcb.29208
dc.identifier.issn1097-4644
dc.identifier.urihttps://hdl.handle.net/1843/42198
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Cellular Biochemistry
dc.rightsAcesso Aberto
dc.subjectCitocinas
dc.subjectTecido adiposo branco
dc.subjectExercícios físicos
dc.subjectFatores de transcrição
dc.subjectMúsculo esquelético
dc.subject.otherCytokines
dc.subject.otherEpididymal tissue
dc.subject.otherGastrocnemius
dc.subject.otherPhysical exercise
dc.subject.otherTranscription factors
dc.subject.otherTribbles 3
dc.titleAerobic training induces differential expression of genes involved in lipid metabolism in skeletal muscle and white adipose tissues
dc.typeArtigo de periódico
local.citation.epage18893
local.citation.issue11
local.citation.spage18883
local.citation.volume120
local.description.resumoAerobic training induces adaptive responses in skeletal muscles and white adipose tissues, thus facilitating lipid utilization as energy substrates during a physical exercise session. However, the effects of training on cytokines levels and on transcription factors involved in lipid metabolism in muscle and different white adipose depots are still unclear; therefore, these were the aims of the present study. Nineteen adult male Wistar rats were randomly assigned to a trained group or a control, non-trained group. The 10-week training protocol consisted of running on a treadmill, during 1 hour per day, 5 days per week, at 75% of maximum aerobic speed. As expected, trained rats improved their aerobic performance and had augmented citrate synthase activity in the soleus, while the control rats did not. Although body weight was not different between groups, the adiposity index and white adipose depots (ie, epididymal and retroperitoneal) were reduced in trained rats. Training reduced serum concentration of insulin, but failed to change serum concentrations of glucose, triacylglycerol, total cholesterol, and nonesterified fatty acids. Training increased sterol regulatory element-binding protein-1c expression in the gastrocnemius and epididymal adipose tissue, and reduced peroxisome proliferator-activated receptor γ (PPARγ) expression in most of the tissues analyzed. The expression of PPARα and carnitine palmitoyltransferase 1 increased in the gastrocnemius and mesenteric adipose tissue but reduced in epididymal adipose tissue. Triacylglycerol content and tribbles 3 expression reduced in the gastrocnemius of trained rats. Tumor necrosis factor-α and interleukin-6 were increased in all adipose depots evaluated. Collectively, our data indicate that the 10-week aerobic training changed gene expression to improve muscle oxidative metabolism and facilitate lipid degradation in adipose tissues. Our data also highlight the existence of adaptive responses that are distinct between the skeletal muscle and white adipose tissue and between different adipose depots.
local.identifier.orcidhttps://orcid.org/ 0000-0002-4659-1032
local.identifier.orcidhttps://orcid.org/0000-0002-5705-8890
local.identifier.orcidhttps://orcid.org/0000-0003-2256-8652
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/jcb.29208

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