Peripheral giant cell granuloma: an updated analysis of 2824 cases reported in the literature

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dc.creatorBruno Ramos Chrcanovic
dc.creatorCarolina Cavalieri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-07-11T20:32:30Z
dc.date.accessioned2025-09-08T23:44:06Z
dc.date.available2025-07-11T20:32:30Z
dc.date.issued2018-05
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12706
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/83526
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectGranuloma, giant cell
dc.subjectTherapeutics
dc.subjectRadiology
dc.subjectPrevalence
dc.subjectRecurrence
dc.subjectExcision repair
dc.subjectOsteotomy
dc.subjectMandible
dc.subjectCarrier state
dc.subjectCurettage
dc.subject.otherClinical features
dc.subject.otherGiant cell lesion
dc.subject.otherPeripheral giant cell granuloma
dc.subject.otherRecurrence rate
dc.subject.otherTreatment.
dc.titlePeripheral giant cell granuloma: an updated analysis of 2824 cases reported in the literature
dc.typeArtigo de periódico
local.citation.epage459
local.citation.issue5
local.citation.spage454
local.citation.volume47
local.description.resumoAbstract Objective: To integrate the available data published on peripheral giant cell granuloma (PGCG) into a comprehensive analysis of its clinical/radiological features. Materials and methods: An electronic search was undertaken in January 2018 in 5 databases, looking for publications reporting cases of PGCGs. Probability of recurrence was calculated for some variables. Results: A total of 165 publications were included, 2824 lesions identified. PGCGs were slightly more prevalent in women and more prevalent in mandibles, usually asymptomatic, and presenting erosion of the subjacent bone in almost one-third of cases. Additional curettage (2.8%) or peripheral osteotomy (0%) after excision presented lower recurrence rates in comparison with excision alone (16%). Excision followed by curettage decreases the probability of recurrence by 85% in comparison with excision alone. Other factors (age, lesion size, follow-up, gender, location, clinical symptoms, bone erosion) seem to do not influence the probability of recurrence. Conclusions: As surgical excision alone shows a considerable recurrence rate, excision followed by an additional therapy-curettage or peripheral osteotomy-should be the first choice of treatment of PGCG.
local.identifier.orcidhttps://orcid.org/0000-0002-3460-3374
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12706

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