Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma

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dc.creatorSmitha Sammith Shetty
dc.creatorMohit Sharma
dc.creatorFelipe Paiva Fonseca
dc.creatorRaghu Radhakrishnan
dc.creatorPradyumna Jayaram
dc.creatorAnkit Singh Tanwar
dc.creatorShama Prasada Kabekkodu
dc.creatorSatyamoorthy Kapaettu
dc.date.accessioned2024-01-29T18:07:55Z
dc.date.accessioned2025-09-08T23:35:02Z
dc.date.available2024-01-29T18:07:55Z
dc.date.issued2020-08-22
dc.identifier.doihttps://doi.org/10.1016%2Fj.jdsr.2020.07.002
dc.identifier.issn18827616
dc.identifier.urihttps://hdl.handle.net/1843/63463
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJapanese dental science review
dc.rightsAcesso Aberto
dc.subjectEpithelial-mesenchymal transition
dc.subjectOral submucous fibrosis
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectTranscription Factors
dc.subjectNeoplasms
dc.subjectGenes
dc.subjectDown-regulation
dc.subjectUp-regulation
dc.subject.otherSignaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma assunto Epithelial-Mesenchymal Transition busca dia 27 do 10 2023 fao clínica open acess
dc.subject.otherJapanese dental science review
dc.titleSignaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage108
local.citation.issue1
local.citation.spage97
local.citation.volume56
local.description.resumoEpithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent to fibrosis in the onset of oral submucous fibrosis (OSF) and the role of EMT in its malignant transformation indicates a hitherto unexplored involvement of EMT. This review focuses on the role of EMT markers which are regulators of the EMT mediated complex network of molecular mechanisms involved in the pathogenesis of OSF and OSCC. Further the gene enrichment analysis and pathway analysis supports the association of the upregulated and downregulated genes in various EMT regulating pathways.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452314/

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