CD1a+ dendritic cells in oral lichen planus and amalgam lichenoid reaction

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dc.creatorGiovanna Ribeiro Souto
dc.creatorLaiz Fernandes Mendes Nunes
dc.creatorBarbara Brandão Tanure
dc.creatorRicardo Santiago Gomez
dc.creatorRicardo Alves de Mesquita
dc.date.accessioned2024-11-12T19:18:56Z
dc.date.accessioned2025-09-09T01:32:30Z
dc.date.available2024-11-12T19:18:56Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2016.02.009
dc.identifier.issn2212-4411
dc.identifier.urihttps://hdl.handle.net/1843/77991
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsAcesso Restrito
dc.subjectCell Count
dc.subjectDendritic cells
dc.subjectLichen planus, oral
dc.subjectMouth mucosa
dc.subjectImmunohistochemistry
dc.subjectDiagnosis
dc.subjectEvaluation study
dc.titleCD1a+ dendritic cells in oral lichen planus and amalgam lichenoid reaction
dc.typeArtigo de periódico
local.citation.epage656
local.citation.issue6
local.citation.spage651
local.citation.volume121
local.description.resumoObjective: To evaluate and compare the number of CD1a+ dendritic cells (DCs) in oral lichen planus (OLP), amalgam lichenoid reaction (ALR), and normal oral mucosa (NOM). Study design: Fourteen cases of OLP and ALR, diagnosed both clinically and histologically, were obtained from an archive of an oral pathology service. Seven specimens of NOM were collected and served as controls. Immunohistochemistry was used to identify CD1a+ DCs. Densities were calculated using specimens of epithelium and lamina propria. For OLP and ALR, specimens of lamina propria included cells from inflammatory infiltrate (region A), and from below inflammatory infiltrate (region B). Comparisons and statistical analyses were performed among OLP, ALR, and NOM. Results: A higher density of CD1a+ DCs was observed in OLP compared to ALR in region A (P < .05) and regions A+B (P < .05). A higher density of CD1a+ DCs was also observed in OLP compared with NOM in the regions A+B (P < .05). Statistically significant differences were not observed for analyses involving epithelial tissue. Conclusions: The observation that there is a lower quantity of DCs in ALR specimens compared with specimens from individuals with OLP suggests that the role for DCs in the 2 diseases may be different. The difference in cell density could be used in the differential diagnosis of these 2 diseases, but the overlapping intervals in the statistical analysis may limit the application of this approach in surgical practice.
local.identifier.orcidhttps://orcid.org/0000-0003-3617-8794
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440316000687?via%3Dihub

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