Solid-state characterization and pharmaceutical compatibility between citalopram and excipients using thermal and non-thermal techniques

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dc.creatorSumaia Araújo Pires
dc.creatorWagner da Nova Mussel
dc.creatorMaria Irene Yoshida
dc.date.accessioned2023-03-03T18:18:32Z
dc.date.accessioned2025-09-09T01:22:05Z
dc.date.available2023-03-03T18:18:32Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s10973-016-5769-z
dc.identifier.issn1588-2926
dc.identifier.urihttps://hdl.handle.net/1843/50648
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Restrito
dc.subjectAnálise térmica
dc.subjectCalorimetria
dc.subjectRaios X - Difração
dc.subjectRessonância magnética nuclear
dc.subjectMedicamentos - Estabilidade
dc.subjectPolimorfismo (Cristalografia)
dc.subjectQuímica do estado sólido
dc.subjectQuímica farmacêutica
dc.subjectExcipientes
dc.subjectFármacos
dc.subjectAntidepressivos
dc.subject.otherCitalopram
dc.subject.otherCompatibility studies
dc.subject.otherThermal analysis
dc.subject.otherPXRD
dc.subject.otherSSNMR
dc.titleSolid-state characterization and pharmaceutical compatibility between citalopram and excipients using thermal and non-thermal techniques
dc.typeArtigo de periódico
local.citation.epage542
local.citation.issue1
local.citation.spage535
local.citation.volume127
local.description.resumoDifferential scanning calorimetry (DSC) has been used in combination with powder X-ray diffraction (PXRD) and solid-state nuclear magnetic resonance (SSNMR) for evaluation of drug–excipient interaction. This study aimed to evaluate the antidepressive citalopram hydrobromide and the most usual excipient commonly used for the evaluation of their compatibility in binary mixtures. The TG/DTG curves reveal that citalopram is thermally stable up to 230 °C, presenting a sharp endothermic peak at 183 °C (T onset = 185 °C) that corresponds to its melting point. Only for citalopram–lactose binary mixture was observed dislocation of the melting event in the DSC curves; however, this change has not indicated to be an interaction between the components in this case, but an overlap of events of lactose and citalopram. PXRD pattern suggests that no interaction is present between individual components that still showing the same crystalline structure for citalopram. The SSNMR spectrum assignment was done based on computational prediction of chemical shifts comparing it with its original spectrum. The chemical shifts confirmed the expected structure. Therefore, since changes in chemical shift are smaller than 1 ppm, no evidence of chemical interaction between the components of each binary mixture was confirmed.
local.identifier.orcidhttps://orcid.org/0000-0001-7611-7545
local.identifier.orcidhttps://orcid.org/0000-0002-9768-9830
local.identifier.orcidhttps://orcid.org/0000-0002-6795-9457
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10973-016-5769-z

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