Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice

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dc.creatorGabriela Cavazza Cerri
dc.creatorLeandro Ceotto Freitas Lima
dc.creatorDeborah de Farias Lelis
dc.creatorLucíola da Silva Barcelos
dc.creatorJohn David Feltenberger
dc.creatorSamuel Vidal Mussi
dc.creatorRenato Sobral Monteiro Júnior
dc.creatorRobson Augusto Souza dos Santos
dc.creatorLucas Antônio Miranda Ferreira
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-29T15:12:45Z
dc.date.accessioned2025-09-08T23:48:18Z
dc.date.available2022-08-29T15:12:45Z
dc.date.issued2019-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2018.12.063
dc.identifier.issn0024-3205
dc.identifier.urihttps://hdl.handle.net/1843/44664
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofLife Sciences
dc.rightsAcesso Restrito
dc.subjectObesidade
dc.subjectDiterpenos
dc.subjectEssências e óleos essenciais
dc.subjectTecido adiposo
dc.subjectNanopartículas
dc.titleSclareol-loaded lipid nanoparticles improved metabolic profile in obese mice
dc.typeArtigo de periódico
local.citation.epage299
local.citation.spage292
local.citation.volume218
local.description.resumoSclareol is a bioactive hydrophobic diterpene in the essential oil isolated from Salvia sclarea (Fam. Lamiaceae). Sclareol has been widely studied due to its anti-inflammatory and antioxidant effects. Aims: the present study aimed to evaluate the effects of Sclareol in different formulations (solid lipid nanoparticle and free) on the metabolic profile of obese mice. Main methods: swiss male mice were randomly divided into two groups: standard diet (STD) and high-fat diet (HFD). After obesity induction, each group was divided into three treatment groups: free Sclareol (Sc), Sclareol-loaded lipid nanoparticle (L-Sc) and blank lipid nanoparticle (L). Treatments were performed every day during 30 days. Key findings: L-Sc improves obese mice metabolic profile by decreasing adiposity, ameliorating insulin sensitivity, glucose tolerance and increasing the HDL plasma levels. In addition, L-Sc decreased the expression of NF-KB, MCP-1 and SERBP-1. Significance: the use of sclareol together with lipid nanocarriers may be promising for the treatment of metabolic disorders by reducing adipose tissue.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0024320518308609

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