Transient abnormalities in masking tuning curve in early progressive hearing loss mouse model

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dc.creatorMarion Souchal
dc.creatorLudimila Labanca
dc.creatorSirley Alves da Silva Carvalho
dc.creatorLuciana Macedo de Resende
dc.creatorChristelle Blavignac
dc.creatorPaul Avan
dc.creatorFabrice Giraudet
dc.date.accessioned2023-08-09T21:26:27Z
dc.date.accessioned2025-09-09T00:58:38Z
dc.date.available2023-08-09T21:26:27Z
dc.date.issued2018-02-13
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1155/2018/6280969
dc.identifier.issn2314-6133
dc.identifier.urihttps://hdl.handle.net/1843/57669
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBioMed Research International
dc.rightsAcesso Aberto
dc.subjectPerda Auditiva Condutiva-Neurossensorial Mista
dc.subjectCélulas Ciliadas Auditivas Externas
dc.subject.otherSensorineural hearing losses
dc.subject.otherCochlear outer hair cells
dc.titleTransient abnormalities in masking tuning curve in early progressive hearing loss mouse model
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage1
local.citation.volume2018
local.description.resumoDamage to cochlear outer hair cells (OHCs) usually affects frequency selectivity in proportion to hearing threshold increase. However, the current clinical heuristics that attributes poor hearing performance despite near-normal auditory sensitivity to auditory neuropathy or “hidden” synaptopathy overlooks possible underlying OHC impairment. Here, we document the part played by OHCs in influencing suprathreshold auditory performance in the presence of noise in a mouse model of progressive hair cell degeneration, the CD1 strain, at postnatal day 18–30 stages when high-frequency auditory thresholds remained near-normal. Nonetheless, total loss of high-frequency distortion product otoacoustic emissions pointed to nonfunctioning basal OHCs. This “discordant profile” came with a huge low-frequency shift of masking tuning curves that plot the level of interfering sound necessary to mask the response to a probe tone, against interfering frequency. Histology revealed intense OHC hair bundle abnormalities in the basal cochlea uncharacteristically associated with OHC survival and preserved coupling with the tectorial membrane. This pattern dismisses the superficial diagnosis of “hidden” neuropathy while underpinning a disorganization of cochlear frequency mapping with optimistic high-frequency auditory thresholds perhaps because responses to high frequencies are apically shifted. The audiometric advantage of frequency transposition is offset by enhanced masking by low-frequency sounds, a finding essential for guiding rehabilitation.
local.identifier.orcidhttps://orcid.org/0000-0003-3296-4800
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE FONOAUDIOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.hindawi.com/journals/bmri/2018/6280969/

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