Pan-resistome insights into the multidrug resistance of Acinetobacter baumannii

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dc.creatorDiego Lucas Neres Rodrigues
dc.creatorFrancielly Morais Rodrigues
dc.creatorRaquel Hurtado
dc.creatorRoselane Gonçalves dos Santos
dc.creatorDaniela Camargos Costa
dc.creatorDebmalya Barh
dc.creatorPreetam Ghosh
dc.creatorKhalid J. Alzahran
dc.creatorSiomar Castro Soares
dc.creatorRommel Ramos
dc.creatorAristóteles Góes Neto
dc.creatorVasco Azevedo
dc.creatorFlávia Figueira Aburjaile
dc.date.accessioned2025-01-20T23:07:15Z
dc.date.accessioned2025-09-08T23:30:52Z
dc.date.available2025-01-20T23:07:15Z
dc.date.issued2021-05-18
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/antibiotics10050596
dc.identifier.issn2079-6382
dc.identifier.urihttps://hdl.handle.net/1843/79346
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAntibiotics
dc.rightsAcesso Aberto
dc.subjectBacteriologia
dc.subjectPatologia
dc.subjectMicrobiologia
dc.subject.otherAntimicrobial
dc.subject.otherDrug resistance
dc.subject.otherPan-genome
dc.subject.otherMultilocus sequence typing
dc.subject.otherNosocomial infections
dc.titlePan-resistome insights into the multidrug resistance of Acinetobacter baumannii
dc.typeArtigo de periódico
local.citation.epage19
local.citation.issue5
local.citation.spage1
local.citation.volume10
local.description.resumoAcinetobacter baumannii is an important Gram-negative opportunistic pathogen that is responsible for many nosocomial infections. This etiologic agent has acquired, over the years, multiple mechanisms of resistance to a wide range of antimicrobials and the ability to survive in different environments. In this context, our study aims to elucidate the resistome from the A. baumannii strains based on phylogenetic, phylogenomic, and comparative genomics analyses. In silico analysis of the complete genomes of A. baumannii strains was carried out to identify genes involved in the resistance mechanisms and the phylogenetic relationships and grouping of the strains based on the sequence type. The presence of genomic islands containing most of the resistance gene repertoire indicated high genomic plasticity, which probably enabled the acquisition of resistance genes and the formation of a robust resistome. A. baumannii displayed an open pan-genome and revealed a still constant genetic permutation among their strains. Furthermore, the resistance genes suggest a specific profile within the species throughout its evolutionary history. Moreover, the current study performed screening and characterization of the main genes present in the resistome, which can be used in applied research to develop new therapeutic methods to control this important bacterial pathogen.
local.identifier.orcidhttps://orcid.org/0000-0003-2812-3072
local.identifier.orcidhttps://orcid.org/0000-0002-1902-530X
local.identifier.orcidhttps://orcid.org/0000-0001-7821-1471
local.identifier.orcidhttps://orcid.org/0000-0001-8904-332X
local.identifier.orcidhttps://orcid.org/0000-0002-2557-7768
local.identifier.orcidhttps://orcid.org/0000-0003-3880-5886
local.identifier.orcidhttps://orcid.org/0000-0002-6688-0106
local.identifier.orcidhttps://orcid.org/0000-0001-7299-3724
local.identifier.orcidhttps://orcid.org/0000-0002-7692-6243
local.identifier.orcidhttps://orcid.org/0000-0002-4775-2280
local.identifier.orcidhttps://orcid.org/0000-0002-1067-1882
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2079-6382/10/5/596

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