Soluble endoglin in urine as an early-pregnancy preeclampsia marker: antenatal longitudinal feasibility study

Página do item simplificado
dc.creatorZilma Silveira Nogueira Reis
dc.creatorJacqueline Braga Pereira
dc.creatorLúcia Aparecida c. Costa
dc.creatorJuliana Silva Barra
dc.date.accessioned2023-07-31T21:18:04Z
dc.date.accessioned2025-09-08T23:46:19Z
dc.date.available2023-07-31T21:18:04Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1080/01443615.2020.1789851
dc.identifier.issn01443615
dc.identifier.urihttps://hdl.handle.net/1843/57272
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.rightsAcesso Restrito
dc.subjectIndutores da Angiogênese
dc.subjectPré-Eclâmpsia
dc.subjectGestantes
dc.subject.otherAngiogenesis
dc.subject.otherPreeclampsia
dc.subject.otherPregnant woman
dc.titleSoluble endoglin in urine as an early-pregnancy preeclampsia marker: antenatal longitudinal feasibility study
dc.typeArtigo de periódico
local.citation.epage698
local.citation.issue5
local.citation.spage693
local.citation.volume41
local.description.resumoThis study aimed to evaluate soluble endoglin (sEng) in urine as a preeclampsia predictor. Ninety-three pregnant women at risk for preeclampsia were followed. Spot urine sample ELISA analysis before 20 weeks of gestation was done to assess protein levels. Logistic regression analysis evaluated associations between preeclampsia with sEng/creatinine ratio, pg/mg, adjusted for risk factors. Preeclampsia incidence was 22.8% (20/92). Urinary sEng/creatinine (pg/mg) 0.001 (95% CI 0.001–0.136) was associated, adjusted for body mass index > 28 kg/m2 OR 6.44 (95% CI 1.11–37.47) and mean arterial pressure OR 1.20 (1.07–1.35). During the first half of gestation sEng urinary excretion was lower in pregnant women developing preeclampsia.IMPACT STATEMENT: What is already known on this subject? The angiogenesis factors present in the plasma of pregnant women have shown good preclinical predictors of preeclampsia. Studies on urinary markers in pregnancy are infrequent, despite the ease of obtaining urine specimens. What do the results of this study add? Values of the sEng/creatinine ratio during the first half of pregnancy were related to a higher chance of preeclampsia occurring when it was evaluated alone or adjusted by body mass index and mean arterial pressure values. What are the implications of these findings for clinical practice and/or further research? The potential benefits of a urinary test compared to one of the blood levels include its non-invasive nature and ease of performing the test, even during prenatal care. Future research is expected to evaluate the sEng/creatinine ratio relevance to improve clinical scores of preeclampsia prediction for the identification of women at risk for this disease.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/full/10.1080/01443615.2020.1789851

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG