Role of yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis

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dc.creatorMohit Sharma
dc.creatorKeith Hunter
dc.creatorFelipe Paiva Fonseca
dc.creatorSmitha Sammith Shetty
dc.creatorRaghu Radhakrishnan
dc.date.accessioned2023-11-27T20:20:37Z
dc.date.accessioned2025-09-09T01:23:53Z
dc.date.available2023-11-27T20:20:37Z
dc.date.issued2021-08
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2021.105164
dc.identifier.issn00039969
dc.identifier.urihttps://hdl.handle.net/1843/61420
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectCellular senescence
dc.subjectHippo signaling pathway
dc.subjectMouth neoplasms
dc.subjectOral submucous fibrosis
dc.subjectProteins
dc.subject.othercarcinoma epidermoide título periódico Archives of oral biology assunto Cellular Senescence
dc.subject.otheracesso restrito fao clínica busca dia 14 do mes 11 de 2023 Role of yes-associated protein and transcriptional coactivator with pdz-binding motif in the malignant transformation of oral submucous fibrosis
dc.titleRole of yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis
dc.typeArtigo de periódico
local.citation.spage105164
local.citation.volume128
local.description.resumoObjective(s): The objective of the present manuscript is to elucidate the role of matrix stiffness in the malignant transformation of oral submucous fibrosis. Design: The role of matrix stiffness in several cancers including oral cancer was reviewed with a tailored search strategy using relevant keywords as per the Medline format. The role of molecular mediators, Yes-associated protein 1 (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) was weighed in the context of OSF along two distinct pathways. Results: Increased matrix stiffness activates the transcriptional coactivators, YAP and TAZ shuttling between the nucleus and cytoplasm. YAP and TAZ, serve as mechanical transducers in promoting cell migration, invasion and epithelial-mesenchymal transition (EMT). The hypoxic microenvironment in the advanced stage of OSF promotes the migratory phenotype through mechanical memory. Conclusions: Reprogramming of a stiff matrix has the potential to restore the Hippo-YAP/TAZ tumor suppressor pathway and reverse fibrosis-associated tumor development.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996921001278?via%3Dihub

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