Effectiveness and safety of anti-TNF in psoriatic arthritis patients in Brazil: a post-incorporation analysis

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dc.creatorMichael Ruberson Ribeiro da Silva
dc.creatorJéssica Barreto Ribeiro dos Santos
dc.creatorAlessandra Maciel Almeida
dc.creatorAdriana Maria Kakehasi
dc.creatorHaliton Alves de Oliveira Júnior
dc.creatorJuliana Álvares-Teodoro
dc.creatorFrancisco de Assis Acurcio
dc.date.accessioned2025-04-17T00:27:34Z
dc.date.accessioned2025-09-08T23:56:23Z
dc.date.available2025-04-17T00:27:34Z
dc.date.issued2018-10-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.2217/cer-2018-0017
dc.identifier.issn2042-6305
dc.identifier.urihttps://hdl.handle.net/1843/81677
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of comparative effectiveness research
dc.rightsAcesso Restrito
dc.subjectArtrite
dc.subject.otherAnti-TNF
dc.subject.otherArtrite psoriática
dc.subject.otherAnálise pós-incorporação
dc.subject.otherEstudo de coorte
dc.titleEffectiveness and safety of anti-TNF in psoriatic arthritis patients in Brazil: a post-incorporation analysis
dc.typeArtigo de periódico
local.citation.epage1000
local.citation.issue10
local.citation.spage989
local.citation.volume7
local.description.resumoAim: Psoriatic arthritis is a chronic disease that can result in disability and decreased quality of life. Materials & methods: A prospective cohort was conducted in Brazil. Disease activity was measured by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Clinical Disease Activity Index (CDAI), functionality by the Health Assessment Questionnaire Disability Index (HAQ-DI) and the quality of life by the EuroQol 5D (EQ-5D). Results: In total, 122 patients were included. After 6 months, a median reduction of 2.03 in the BASDAI, 7.80 in the CDAI, 0.63 in the HAQ-DI and increase of 0.12 in the EQ-5D was observed. A good clinical response was observed in 45.5% of the patients by BASDAI and 54.5% by CDAI. Higher education and better quality of life were identified as predictors of effectiveness. The most common side effects were the infections. Conclusion: Anti-TNF-α drugs were effective and safe. The incorporation of them into the Brazilian Public Health System has provided therapeutic alternatives to the treatment of psoriatic arthritis.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://becarispublishing.com/doi/10.2217/cer-2018-0017

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